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Comment
. 2017 Aug 3;18(8):545-546.
doi: 10.1080/15384047.2017.1345398. Epub 2017 Jul 5.

Discussing the predictive, prognostic, and therapeutic value of germline DNA-repair gene mutations in metastatic prostate cancer patients

Ralph J Hauke Jr  1 , Tristan M Sissung  2 , William D Figg  1   2
Affiliations
Comment

Discussing the predictive, prognostic, and therapeutic value of germline DNA-repair gene mutations in metastatic prostate cancer patients

Ralph J Hauke Jr et al. Cancer Biol Ther. .

Abstract

Recent trends in cancer therapy have begun emphasizing the use of precision medicine, especially genetic tools, in the evaluation of malignancies and decision-making. Prostate cancer is a malignancy where the benefits and utility of screening and early treatment are still heavily controversial. A recent paper in the New England Journal of Medicine found that patients with metastatic prostate cancer presented germline mutations in DNA-repair genes at a significantly higher incidence than those with localized prostate cancer. These findings indicate the need for further research in this field as genetic differences between metastatic and localized prostate cancer could have great clinical value.

Keywords: CRPC; Cancer therapy; DNA-repair genes; genetic testing; genomics; germline mutations; prostate cancer.

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Comment on

  • Inherited DNA-Repair Gene Mutations in Men with Metastatic Prostate Cancer.
    Pritchard CC, Mateo J, Walsh MF, De Sarkar N, Abida W, Beltran H, Garofalo A, Gulati R, Carreira S, Eeles R, Elemento O, Rubin MA, Robinson D, Lonigro R, Hussain M, Chinnaiyan A, Vinson J, Filipenko J, Garraway L, Taplin ME, AlDubayan S, Han GC, Beightol M, Morrissey C, Nghiem B, Cheng HH, Montgomery B, Walsh T, Casadei S, Berger M, Zhang L, Zehir A, Vijai J, Scher HI, Sawyers C, Schultz N, Kantoff PW, Solit D, Robson M, Van Allen EM, Offit K, de Bono J, Nelson PS. Pritchard CC, et al. N Engl J Med. 2016 Aug 4;375(5):443-53. doi: 10.1056/NEJMoa1603144. Epub 2016 Jul 6. N Engl J Med. 2016. PMID: 27433846 Free PMC article.

References

    1. Siegel RL, Miller KD, Jemal A. Cancer statistics, 2016. CA Cancer J Clin 2016; 66(1):7-30; PMID:26742998; https://doi.org/10.3322/caac.21332 - DOI - PubMed
    1. Loeb S, Nicholson J, Tammela TL, Penson DF, Carter HB, Carroll P, Etzioni R.. Overdiagnosis and overtreatment of prostate cancer. Eur Urol 2014; 65(6):1046-55; PMID:24439788; https://doi.org/10.1016/j.eururo.2013.12.062 - DOI - PMC - PubMed
    1. Mucci LA, Hjelmborg JB, Harris JR, Czene K, Havelick DJ, Scheike T, Graff RE, Holst K, Möller S, Unger RH, et al.. Familial Risk and Heritability of Cancer Among Twins in Nordic Countries. JAMA 2016; 315(1):68-76; PMID:26746459; https://doi.org/10.1001/jama.2015.17703 - DOI - PMC - PubMed
    1. Robinson D, Van Allen EM, Wu YM, Schultz N, Lonigro RJ, Mosquera JM, Montgomery B, Taplin ME, Pritchard CC, Attard G, et al. Integrative clinical genomics of advanced prostate cancer. Cell 2015; 161(5):1215-28; PMID:26000489; https://doi.org/10.1016/j.cell.2015.05.001 - DOI - PMC - PubMed
    1. Pritchard CC, Mateo J, Walsh MF, De Sarkar N, Abida W, Beltran H, Garofalo A, Gulati R, Carreira S, Eeles R, et al.. Inherited DNA-Repair Gene Mutations in Men with Metastatic Prostate Cancer. N Engl J Med 2016; 375(5):443-53; PMID:27433846; https://doi.org/10.1056/NEJMoa1603144 - DOI - PMC - PubMed

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