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Randomized Controlled Trial
. 2017 May-Jun;25(3):335-340.
doi: 10.1590/1678-7757-2016-0408.

Randomized clinical trial of the effect of NovaMin and CPP-ACPF in combination with dental bleaching

Larissa Dias Alexandrino  1 , Cristiane de Melo Alencar  1 , Ana Daniela Silva da Silveira  1 , Eliane Bemerguy Alves  1 , Cecy Martins Silva  1
Affiliations
Randomized Controlled Trial

Randomized clinical trial of the effect of NovaMin and CPP-ACPF in combination with dental bleaching

Larissa Dias Alexandrino et al. J Appl Oral Sci. 2017 May-Jun.

Abstract

Objective: This randomized, controlled, double-blind clinical study evaluated the effect of calcium sodium phosphosilicate (NovaMin) and casein phosphopeptide-amorphous calcium phosphate with fluoride (CPP-ACPF) on the prevention of post-operative sensitivity and on the effects of clinical bleaching treatment.

Material and methods: Sixty volunteers were selected according to inclusion and exclusion criteria and were randomly assigned into three groups (n=20): CG (control group) patients, who were treated with 35% hydrogen peroxide; NOVAG (NovaMin group) patients, who were treated with 35% hydrogen peroxide followed by the application of NovaMin; and CPPG (CPP group) patients, who were treated with 35% hydrogen peroxide followed by the application of CPP-ACPF. Both bioactive agents were applied for five minutes. An evaporative stimulus associated with a modified visual scale was used to analyze sensitivity 24 hours after each bleaching session. The color evaluation was performed on the maxillary central incisors using a spectrophotometer. Associations between the intervention group, bleaching session, and reported sensitivity were tested using Chi-square partitioning.

Results: Color change values (ΔE) were analyzed using analysis of variance (ANOVA). The significance level used for both tests was 5%. In the intragroup assessment, the Friedman test showed that only the CPP-ACPF group showed no statistically significant difference (p<0.05) between baseline and first bleaching session. In the intergroup assessment, the Kruskal-Wallis test showed that the CPPG had less postoperative sensitivity after the first session, when compared to the other groups (p<0.05). Color change analysis (ΔE) showed a significant difference between the means obtained in the different bleaching sessions in all groups (p<0.05).

Conclusions: This study showed that the combination of CPP-ACPF with 35% hydrogen peroxide significantly reduced post-operative sensitivity in the first session, compared with the other evaluated treatments. The association of CPP-ACPF and NovaMin did not affect the color change induced by tooth bleaching.

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Figures

Figure 1
Figure 1. Inclusion and exclusion criteria
Figure 2
Figure 2. Schematic study design
See this image and copyright information in PMC

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