Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2017 Jul 5;16(1):132.
doi: 10.1186/s12944-017-0515-5.

Effects of aerobic exercise on lipids and lipoproteins

Affiliations
Review

Effects of aerobic exercise on lipids and lipoproteins

Yating Wang et al. Lipids Health Dis. .

Abstract

Dyslipidemia is the risk of cardiovascular disease, and their relationship is clear. Lowering serum cholesterol can reduce the risk of coronary heart disease. At present, the main treatment is taking medicine, however, drug treatment has its limitations. Exercise not only has a positive effect on individuals with dyslipidemia, but can also help improve lipids profile. This review is intending to provide information on the effects of exercise training on both tranditional lipids, for example, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, triglycerides and new lipids and lipoproteins such as non-high-density lipoprotein cholesterol, and postprandial lipoprotein. The mechanisms of aerobic exercise on lipids and lipoproteins are also briefly described.

Keywords: Aerobic exercise; Coronary heart disease; Dyslipidemia; Lipoprotein.

PubMed Disclaimer

Figures

Fig. 1
Fig. 1
Summary of the potential mechanisms through which exercise improves the lipid profile. Legend: Exercise leads TG consumed by muscle tissue and increases LPL which results in more TG hydrolysis. Less PCSK9 makes more LDL absorbed and excreted by the liver. Upregulation of LXR increased ABCA1 expression in macrophage and then promoted RCT process, which results more cholesterol transported to the liver via HDL

References

    1. Lewington S, Whitlock G, Clarke R, et al. Blood cholesterol and vascular mortality by age, sex, and blood pressure: a meta-analysis of individual data from 61 prospective studies with 55000 vascular deaths. Lancet. 2007;370:1829–1839. doi: 10.1016/S0140-6736(07)61778-4. - DOI - PubMed
    1. Toth PP, Barter PJ, Rosenson RS, et al. High-densith lipoproteins: a consensus statement from the National Lipid Association. J Clin Lipidol. 2013;7:484–525. doi: 10.1016/j.jacl.2013.08.001. - DOI - PubMed
    1. Goff DC, Jr, Lloyd-Jones DM, Bennett G, et al. 2013 ACC/AHA guideline on the assessment of cardiovascular risk: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. Circulation. 2014;129(suppl 2):S49–S73. doi: 10.1161/01.cir.0000437741.48606.98. - DOI - PubMed
    1. Nordestgaard BG, Wootton R, Lewis B. Selective retention of VLDL, ODL, and LDL in the arterial intima of genetically hyperlipidemic rabbits in vivo. Molecular size as a determinant of fractional loss from the intima-inner media. Arterioscler Thromb Vasc Biol. 1995;15:534–542. doi: 10.1161/01.ATV.15.4.534. - DOI - PubMed
    1. Nordestgaard BG, Benn M, Schnohr P, Tybjaerg-Hansen A. Nonfasting triglycerides and risk of myocardial infarction, ischemic heart disease, and death in men and women. JAMA. 2007;298:299–308. doi: 10.1001/jama.298.3.299. - DOI - PubMed