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. 2017 Jan 25;36(1):54-61.
doi: 10.1515/jomb-2016-0028. eCollection 2017 Jan.

Evaluation of Renal Function in Alzheimer's Disease and Geriatric Patients: Results from a Turkish Two-center Study

Zubeyde Erbayraktar  1 , Ahmet Turan Evlice  2 , Gokhan Yilmaz  3 , Canan Yazici  4 , Gorsev Yener  5 , Nuriye Nuray Ulusu  6
Affiliations

Evaluation of Renal Function in Alzheimer's Disease and Geriatric Patients: Results from a Turkish Two-center Study

Zubeyde Erbayraktar et al. J Med Biochem. .

Abstract
in English, Serbian

Background: Alzheimer's disease (AD) is a severe multifactorial neurodegenerative proteopathy associated with advanced age. Discrepancies in the renal function of these patients compared to geriatric patients with dementia have rarely been reported. In this study, we aimed to disclose the importance of associated renal changes for the pathogenesis of AD.

Methods: Patients with AD (n=107) and geriatric patients with dementia and without dementia (n=124) (231 patients in total) from Dokuz Eylul and Cukurova University Hospitals were enrolled in the study. We measured serum Na, K, Cl, Ca, BUN, creatinine, total protein levels and MDRD [eGFR] in all groups.

Results: From Izmir Center, the first study arm consisted of patients with AD dementia (n=74), and the second arm included geriatric patients with dementia (n=79). From Adana, 78 patients were recruited to the study, of which 33 were with AD and 45 were geriatric patients without dementia. When we analyzed comparatively the AD and geriatric dementia patients study arms, a statistically significant difference was observed both in the median age (p<0.001), as well as in the biochemical parameters from Izmir Center: Na (p<0.001), K (p<0.001), Cl (p<0.05), Ca (p<0.001), BUN (p<0.05), creatinine (p<0.001), total protein (p<0.001) and MDRD [eGFR] (p<0.001). However, these were not significantly different between AD and geriatric patients without dementia in the Adana group.

Conclusions: Our results indicate that renal function is prone to alterations in different age groups of patients with AD. However, there is no conclusive evidence that renal function is one of the risk factors in AD.

Uvod: Alchajmerova bolest (AB) predstavlja tešku multifaktorijalnu neurodegenerativnu proteopatiju koja je povezana sa starenjem. Dosad nije bilo mnogo izveštaja o razlikama u bubrežnoj funkciji kod obolelih od AB i kod gerijatrijskih pacijenata sa demencijom. U ovoj studiji, cilj je bio da se otkrije važnost povezanih promena bubrežne funkcije u patogenezi AB.

Metode: Studija je obuhvatila obolele od AB (n=107) i gerijatrijske pacijente sa demencijom i bez demencije (n=124) (ukupno 231 pacijent) iz bolnica Dokuz Eylul i Univerziteta Cukurova. U svim grupama, izmerili smo serumske nivoe Na, K, Cl, Ca, BUN, kreatinina, ukupnog proteina i MDRD (eGFR).

Rezultati: Iz centra Izmir, kao jednog od dva centra u kojima je studija sprovedena, uključeni su pacijenti sa demencijom AB (n=74) i gerijatrijski pacijenti sa demencijom (n=79). Iz centra Adana, u studiju je uključeno 78 pacijenata, od kojih je 33 imalo AB, dok su 45 bili gerijatrijski pacijenti bez demencije. Kada smo uporedo analizirali pacijente sa AD i gerijatrijskom demencijom, uočene su statistički značajne razlike kako u prosečnoj dobi (p<0,001) tako i u biohemijskim parametrima iz centra Izmir: Na (p<0,001), K (p<0,001), Cl (p<0,001), Ca (p<0,001), BUN (p<0,05), kreatinin (p<0,001), ukupni protein (p<0,001) i MDRD (eGFR) (p<0,001). Međutim, ovi parametri se u grupi Adana nisu značajno razlikovali između obolelih od AB i gerijatrijskih pacijenata bez demencije.

Zaključak: Naši rezultati ukazuju na to da je bubrežna funkcija podložna alteracijama u različitim starosnim grupama obolelih od AB. Međutim, nema čvrstih dokaza da je bubrežna funkcija jedan od faktora rizika za AB.

Keywords: Alzheimer’s disease; dementia; renal function.

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Conflict of interest statement

Conflict of interest statement The authors stated that they have no conflicts of interest regarding the publication of this article.

Figures

Figure 1
Figure 1
Results of serum sodium levels in patients with AD and other types of dementias from the Aegean Region, Izmir, Dokuz Eylul University Hospital.
Figure 2
Figure 2
Results of serum potassium levels in patients with AD and other types of dementias from the Aegean Region, Izmir, Dokuz Eylul University Hospital.
Figure 3
Figure 3
Results of serum creatinine levels in patients with AD and other types of dementias from the Aegean Region, Izmir, Dokuz Eylul University Hospital.
Figure 4
Figure 4
Results of serum BUN levels in patients with AD and other types of dementias from the Aegean region, Izmir, Dokuz Eylul University Hospital.
Figure 5
Figure 5
Results of serum eGFR levels in patients with AD and other types of dementias from the Aegean region, Izmir, Dokuz Eylul University Hospital.
Figure 6
Figure 6
Results of serum total protein levels in patients with AD and other types of dementias from the Aegean region, Izmir, Dokuz Eylul University Hospital.
Figure 7
Figure 7
Results of serum sodium levels in patients with AD and geriatric patients without dementia from the Mediterranean Region, Adana, Cukurova University Hospital.
Figure 8
Figure 8
Results of serum potassium levels in patients with Alzheimer’s and geriatric patients without dementia from the Mediterranean Region, Adana, Cukurova University Hospital.
Figure 9
Figure 9
Results of serum creatinine levels in patients with AD and geriatric patients without dementia from the Mediterranean region, Adana, Cukurova University Hospital.
Figure 10
Figure 10
Results of serum BUN levels in patients with AD and geriatric patients without dementia from the Mediterranean region, Adana, Cukurova University Hospital.
Figure 11
Figure 11
Results of serum eGFR levels in patients with AD and geriatric patients without dementia from the Mediterranean region, Adana, Cukurova University Hospital.
Figure 12
Figure 12
Results of serum total protein levels in patients with AD and geriatric patients without dementia from the Mediterranean region, Adana, Cukurova University Hospital.
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