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Review
. 2017 Jun 21:8:133.
doi: 10.3389/fendo.2017.00133. eCollection 2017.

Alternative RNA Splicing in the Pathogenesis of Liver Disease

Nicholas J G Webster  1   2
Affiliations
Review

Alternative RNA Splicing in the Pathogenesis of Liver Disease

Nicholas J G Webster. Front Endocrinol (Lausanne). .

Abstract

Non-alcoholic fatty liver disease (NAFLD) is becoming increasingly prevalent due to the worldwide obesity epidemic and currently affects one-third of adults or about one billion people worldwide. NAFLD is predicted to affect over 50% of the world's population by the end of the next decade. It is the most common form of liver disease and is associated with increased risk for progression to a more severe form non-alcoholic steatohepatitis, as well as insulin resistance, type 2 diabetes mellitus, cirrhosis, and eventually hepatocellular carcinoma. This review article will focus on the role of alternative splicing in normal liver physiology and dysregulation in liver disease.

Keywords: RNA splicing; hepatocellular carcinoma; microarrays; non-alcoholic fatty liver disease; splicing factors.

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