Indexes of cerebral autoregulation do not reflect impairment in syncope: insights from head-up tilt test of vasovagal and autonomic failure subjects

Abstract

Purpose: The study of dynamic cerebral autoregulation (CA), which adapts cerebral blood flow to arterial blood pressure (ABP) fluctuations, has been limited in orthostatic intolerance syndromes, mainly due to its stationary prerequisites hardly to meet during maneuvers to provoke syncope itself. New techniques of continuous estimates of CA could overcome this pitfall. We aimed to evaluate CA during head-up tilt test in common conditions causing syncope.

Methods: We compared three groups: eight controls; eight patients with autonomic failure due to familial amyloidotic polyneuropathy; eight patients with vasovagal syncope (VVS). ABP and cerebral blood flow velocity (CBFV) were measured with Finometer^® and transcranial Doppler. We calculated cerebrovascular resistance index (CVRi), critical closing pressure (CrCP) and resistance area product (RAP), and derived CA continuously from autoregulation index [ARI(t)].

Results: With HUTT, AF subjects showed a pronounced decrease in CBFV (-36 ± 17 versus -7 ± 6%, p < 0.0001), ABP (-29 ± 27 versus 7 ± 12%, p < 0.0001) and RAP (-17 ± 23 versus 3 ± 18%, p < 0.0001) but not CVRi (p = 0.110). VVS subjects showed progressive cerebral vasoconstriction prior to syncope, (reduced CBFV 19 ± 15 versus 1 ± 6, p < 0.000; increased RAP 12 ± 18 versus 2 ± 3%, p = 0.024 and CVRi 12 ± 18 versus 2 ± 3%, p = 0.005). ARI(t) increased significantly in AF patients (5.7 ± 1.2 versus 6.9 ± 1.2, p = 0.040) and VVS (5.8 ± 1.2 versus 7.3 ± 1.2, p = 0.015) in response to ABP fall during syncope.

Conclusions: Our data suggest that dynamic cerebral autoregulatory response to orthostatic challenge is neither affected by autonomic dysfunction nor in neutrally mediated syncope. This study also emphasizes that RAP + CrCP model is more informative than CVRi, mainly during cerebral vasodilatory response to orthostatic hypotension.

Keywords: Autonomic nervous system; Cerebral blood flow; Cerebral vasoreactivity; Head-up tilt; Orthostatic intolerance; Syncope; Transcranial Doppler.