Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2017 Jun 29;22(26):30565.
doi: 10.2807/1560-7917.ES.2017.22.26.30565.

Co-circulation of multiple subtypes of enterovirus A71 (EV- A71) genotype C, including novel recombinants characterised by use of whole genome sequencing (WGS), Denmark 2016

Sofie E Midgley  1 , Astrid G Nielsen  1 , Ramona Trebbien  1 , Mille W Poulsen  1 , Peter H Andersen  2 , Thea K Fischer  1   3
Affiliations

Co-circulation of multiple subtypes of enterovirus A71 (EV- A71) genotype C, including novel recombinants characterised by use of whole genome sequencing (WGS), Denmark 2016

Sofie E Midgley et al. Euro Surveill. .

Abstract

In Europe, enterovirus A71 (EV-A71) has primarily been associated with sporadic cases of neurological disease. The recent emergence of new genotypes and larger outbreaks with severely ill patients demonstrates a potential for the spread of new, highly pathogenic EV-A71 strains. Detection and characterisation of these new emerging EV variants is challenging as standard EV assays may not be adequate, necessitating the use of whole genome analysis.

Keywords: EV-A71; WGS, NGS, next generation sequencing; enterovirus, classification, Diagnostics, whole genome sequencing.

PubMed Disclaimer

Conflict of interest statement

Conflict of interest: None declared.

Figures

Figure 1
Figure 1
Phylogenetic analysis of enterovirus A71 genotype C cases, Denmark, 2001–2016
Figure 2
Figure 2
Phylogenetic analysis of near-complete genome sequences, enterovirus A71 genotype C cases, Denmark, 2001–2016
Figure 3
Figure 3
Bootscanning and SimPlot analysis of novel enterovirus A71 genotype C cases DK-14–03 (Denmark 2014) and KU641506 (Germany 2015)
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Badran SA, Midgley S, Andersen P, Böttiger B. Clinical and virological features of enterovirus 71 infections in Denmark, 2005 to 2008. Scand J Infect Dis. 2011;43(8):642-8. 10.3109/00365548.2011.577094 - DOI - PubMed
    1. Fischer TK, Nielsen AY, Sydenham TV, Andersen PH, Andersen B, Midgley SE. Emergence of enterovirus 71 C4a in Denmark, 2009 to 2013. Euro Surveill. 2014;19(38):20911. 10.2807/1560-7917.ES2014.19.38.20911 - DOI - PubMed
    1. Zhang Y, Tan X, Cui A, Mao N, Xu S, Zhu Z, et al. Complete genome analysis of the C4 subgenotype strains of enterovirus 71: predominant recombination C4 viruses persistently circulating in China for 14 years. PLoS One. 2013;8(2):e56341. 10.1371/journal.pone.0056341 - DOI - PMC - PubMed
    1. Liu Y, Fu C, Wu S, Chen X, Shi Y, Zhou B, et al. A novel finding for enterovirus virulence from the capsid protein VP1 of EV71 circulating in mainland China. Virus Genes. 2014;48(2):260-72. 10.1007/s11262-014-1035-2 - DOI - PubMed
    1. Böttcher S, Obermeier PE, Neubauer K, Diedrich S, Laboratory Network for Enterovirus Diagnostics Recombinant Enterovirus A71 Subgenogroup C1 Strains, Germany, 2015. Emerg Infect Dis. 2016;22(10):1843-6. 10.3201/eid2210.160357 - DOI - PMC - PubMed

MeSH terms