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. 2017 Jun 29;22(26):30565.
doi: 10.2807/1560-7917.ES.2017.22.26.30565.

Co-circulation of multiple subtypes of enterovirus A71 (EV- A71) genotype C, including novel recombinants characterised by use of whole genome sequencing (WGS), Denmark 2016

Sofie E Midgley  1 , Astrid G Nielsen  1 , Ramona Trebbien  1 , Mille W Poulsen  1 , Peter H Andersen  2 , Thea K Fischer  1   3
Affiliations

Co-circulation of multiple subtypes of enterovirus A71 (EV- A71) genotype C, including novel recombinants characterised by use of whole genome sequencing (WGS), Denmark 2016

Sofie E Midgley et al. Euro Surveill. .

Abstract

In Europe, enterovirus A71 (EV-A71) has primarily been associated with sporadic cases of neurological disease. The recent emergence of new genotypes and larger outbreaks with severely ill patients demonstrates a potential for the spread of new, highly pathogenic EV-A71 strains. Detection and characterisation of these new emerging EV variants is challenging as standard EV assays may not be adequate, necessitating the use of whole genome analysis.

Keywords: EV-A71; WGS, NGS, next generation sequencing; enterovirus, classification, Diagnostics, whole genome sequencing.

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Conflict of interest statement

Conflict of interest: None declared.

Figures

Figure 1
Figure 1
Phylogenetic analysis of enterovirus A71 genotype C cases, Denmark, 2001–2016
Figure 2
Figure 2
Phylogenetic analysis of near-complete genome sequences, enterovirus A71 genotype C cases, Denmark, 2001–2016
Figure 3
Figure 3
Bootscanning and SimPlot analysis of novel enterovirus A71 genotype C cases DK-14–03 (Denmark 2014) and KU641506 (Germany 2015)
See this image and copyright information in PMC

References

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