Génétique et épigénétique des troubles des conduites alimentaires

Abstract

Eating disorders (EDs) are complex and multifactorial psychiatric illnesses that induce significant and sustained pathological disruption of food intake. The Diagnostic and Statistical Manual of Mental Illnesses (DSM-5) describes the clinical criteria of major disorders including anorexia nervosa (AN), bulimia nervosa (BN) and binge eating disorder (BED). The neurobiological basis of food intake is well characterized. Epidemiological studies reported a heritability about 70% in AN and 60% in BN, suggesting that genetic factors are involved in the vulnerability to EDs. The analysis of genetic regions and candidate genes identified several genes associated with AN, including the BDNF gene, encoding a neurotrophic factor and the ESR1 gene, encoding the α-receptor to estrogens. Recent genome-wide association studies (GWAS), carried out on several thousand patients versus controls, identify new candidate genes. Preliminary analyses of methylation levels, for candidate genes or on the whole methylome, suggest that epigenetic signatures are associated with EDs.