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Review
. 2017 Jul 6;13(7):e1006336.
doi: 10.1371/journal.ppat.1006336. eCollection 2017 Jul.

Developing transmission-blocking strategies for malaria control

Robert E Sinden  1
Affiliations
Review

Developing transmission-blocking strategies for malaria control

Robert E Sinden. PLoS Pathog. .
No abstract available

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Conflict of interest statement

The author has declared that no competing interests exist.

Figures

Fig 1
Fig 1. Diagram highlighting the parameters measured by many of the published assays examining the impact of transmission-blocking measures.
The biology examined by each assay is indicated by the arrow length; the precise stage enumerated is indicated by the blue arrowheads. The minimal-desired biology to embrace in a directly informative assay is indicated by the solid green arrow; assays measuring less than this ideal are indicated in red. The population assay (dashed green) can be run over repeated cycles of infection measuring multiple desired “endpoints.” The nonlinear dynamic relationships reported between successive transmission life stages are indicated on the left of the diagram. Illustrative references are: A–C [63], D [64], 1 [65, 66], 2 [49, 51], 3–4 [67], 5 [68, 69], 6 [70], 7 [20, 71], 8 [9, 72], 9 [–75].
See this image and copyright information in PMC

References

    1. Joice R, Narasimhan V, Montgomery J, Sidhu AB, Oh K, Meyer E, et al. Inferring Developmental Stage Composition from Gene Expression in Human Malaria. PLoS Comput Biol. 2013;9(12):e1003392 doi: 10.1371/journal.pcbi.1003392 - DOI - PMC - PubMed
    1. Hall N, Karras M, Raine JD, Carlton JM, Kooij TWJ, Berriman M, et al. A Comprehensive Survey of the Plasmodium Life Cycle by Genomic, Transcriptomic, and Proteomic Analyses. Science. 2005;307:82–6. doi: 10.1126/science.1103717 - DOI - PubMed
    1. Le Roch KG, Zhou Y, Blair PL, Grainger M, Moch K, Haynes D, et al. Discovery of gene function by expression profiling of the malaria parasite life cycle. Science. 2003;301:1503–8. doi: 10.1126/science.1087025 - DOI - PubMed
    1. Griffin JT, Bhatt S, Sinka ME, Gething PW, Lynch M, Patouillard E, et al. Potential for reduction of burden and local elimination of malaria by reducing Plasmodium falciparum malaria transmission: a mathematical modelling study. Lancet Infect Dis. 2016;16:465–72. doi: 10.1016/S1473-3099(15)00423-5 . - DOI - PMC - PubMed
    1. Macdonald G. Theory of the Eradication of Malaria. Bulletin of the World Health Organisation. 1956;15:369–87. - PMC - PubMed

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