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Comment
. 2017 Jul;7(7):666-669.
doi: 10.1158/2159-8290.CD-17-0500.

Improving the Armamentarium of PI3K Inhibitors with Isoform-Selective Agents: A New Light in the Darkness

Jordi Rodon  1 , Josep Tabernero  2
Affiliations
Comment

Improving the Armamentarium of PI3K Inhibitors with Isoform-Selective Agents: A New Light in the Darkness

Jordi Rodon et al. Cancer Discov. 2017 Jul.

Abstract

<b/> Excitement and drug-development efforts aimed at targetable genetic aberrations in the PI3K/AKT/mTOR pathway have declined due to the limited clinical performance of these inhibitors as monotherapies. New, more isoform-selective treatments, such as taselisib, promise to both expand the therapeutic window and increase efficacy. Cancer Discov; 7(7); 666-9. ©2017 AACR.See related article by Juric et al., p. 704.

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