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Comment
. 2017 Sep 1;123(3):684-685.
doi: 10.1152/japplphysiol.00604.2017. Epub 2017 Jul 6.

Point: Exercise training-induced bradycardia is caused by changes in intrinsic sinus node function

Mark R Boyett, Yanwen Wang, Shu Nakao, Jonathan Ariyaratnam, George Hart, Oliver Monfredi, Alicia D'Souza
Comment

Point: Exercise training-induced bradycardia is caused by changes in intrinsic sinus node function

Mark R Boyett et al. J Appl Physiol (1985). .
No abstract available

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Figures

Fig. 1.
Fig. 1.
Evidence against the vagal tone hypothesis: changes in heart rate variability in the study of Billman et al. (3) are primarily determined by heart rate. Main graph shows the relationship between SDNN and heart rate in the study of Billman et al. (3); black points show data from Billman et al. (3); gray points show data from a wide range of published studies (11); the gray line shows the relationship between SDNN and heart rate as determined by a simple biophysical model (11). Inset shows the relationship between high frequency (HF) power and heart rate in the study of Billman et al. (3).
See this image and copyright information in PMC

Comment in

  • Rebuttal from Billman on Point:Counterpoint: Exercise training-induced bradycardia.
    Billman GE. Billman GE. J Appl Physiol (1985). 2017 Sep 1;123(3):690-691. doi: 10.1152/japplphysiol.00607.2017. Epub 2017 Jul 6. J Appl Physiol (1985). 2017. PMID: 28684596 No abstract available.
  • Point:Counterpoint.
    Flannery D, Howden EJ, La Gerche A, Hughson RL, Leicht AS, Boullosa DA, Hautala AJ, Zuo L, He F. Flannery D, et al. J Appl Physiol (1985). 2017 Sep 1;123(3):692-693. doi: 10.1152/japplphysiol.00546.2017. J Appl Physiol (1985). 2017. PMID: 28947627 No abstract available.
  • Last Word on Point:Counterpoint.
    Boyett MR. Boyett MR. J Appl Physiol (1985). 2017 Sep 1;123(3):694. doi: 10.1152/japplphysiol.00542.2017. J Appl Physiol (1985). 2017. PMID: 28947628 Free PMC article. No abstract available.
  • Last Word on Point:Counterpoint.
    Billman GE. Billman GE. J Appl Physiol (1985). 2017 Sep 1;123(3):695. doi: 10.1152/japplphysiol.00495.2017. J Appl Physiol (1985). 2017. PMID: 28947629 No abstract available.

Comment on

References

    1. Aubert AE, Seps B, Beckers F. Heart rate variability in athletes. Sports Med 33: 889–919, 2003. doi:10.2165/00007256-200333120-00003. - DOI - PubMed
    1. Bahrainy S, Levy WC, Busey JM, Caldwell JH, Stratton JR. Exercise training bradycardia is largely explained by reduced intrinsic heart rate. Int J Cardiol 222: 213–216, 2016. doi:10.1016/j.ijcard.2016.07.203. - DOI - PMC - PubMed
    1. Billman GE, Cagnoli KL, Csepe T, Li N, Wright P, Mohler PJ, Fedorov VV. Exercise training-induced bradycardia: evidence for enhanced parasympathetic regulation without changes in intrinsic sinoatrial node function. J Appl Physiol (1985) 118: 1344–1355, 2015. doi:10.1152/japplphysiol.01111.2014. - DOI - PMC - PubMed
    1. Boyett MR, D’Souza A, Zhang H, Morris GM, Dobrzynski H, Monfredi O. Viewpoint: is the resting bradycardia in athletes the result of remodeling of the sinoatrial node rather than high vagal tone? J Appl Physiol (1985) 114: 1351–1355, 2013. doi:10.1152/japplphysiol.01126.2012. - DOI - PubMed
    1. D’Souza A, Bucchi A, Johnsen AB, Logantha SJ, Monfredi O, Yanni J, Prehar S, Hart G, Cartwright E, Wisloff U, Dobryznski H, DiFrancesco D, Morris GM, Boyett MR. Exercise training reduces resting heart rate via downregulation of the funny channel HCN4. Nat Commun 5: 3775, 2014. - PMC - PubMed

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