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. 2017 Jul;7(1):79-84.
doi: 10.3892/br.2017.924. Epub 2017 Jun 7.

Increased neutrophil-to-lymphocyte ratio is a novel marker for nutrition, inflammation and chemotherapy outcome in patients with locally advanced and metastatic esophageal squamous cell carcinoma

Yu Sato  1   2 , Kenji Gonda  2   3 , Maiko Harada  4 , Yuki Tanisaka  4 , Shin Arai  4 , Yumi Mashimo  4 , Hirotoshi Iwano  4 , Hiroshi Sato  5 , Shomei Ryozawa  4 , Takao Takahashi  6 , Shinichi Sakuramoto  5 , Masahiko Shibata  7
Affiliations

Increased neutrophil-to-lymphocyte ratio is a novel marker for nutrition, inflammation and chemotherapy outcome in patients with locally advanced and metastatic esophageal squamous cell carcinoma

Yu Sato et al. Biomed Rep. 2017 Jul.

Abstract

Esophageal squamous cell carcinoma (ESCC) is one of the most common types of cancer, and its progression is strongly influenced by the presence of inflammation. Recently, there has been growing interest in the host inflammatory response, and increasing evidence has indicated that the neutrophil-to-lymphocyte ratio (NLR), a useful marker of systemic inflammation, may be an effective prognostic indicator in various types of malignant diseases. In the present study, 260 patients with ESCC were enrolled, including 110 who received chemoradiation therapy (CRT) involving irradiation and chemotherapy of 5-fluorouracil and cisplatin, and 150 received chemotherapy using 5-fluorouracil and cisplatin (FP). The patients of each group were both divided into two groups according to their NLR: High NLR (NLR>3.0) and low NLR (NLR≤3.0). Serum levels of prealbumin and retinol binding protein, which are nutritional parameters, were both significantly inversely correlated with NLR in patients treated with CRT, and patients treated with FP. Levels of CRP, a marker of inflammation, were significantly correlated with NLR, and stimulation indices, markers of immune reactions, were inversely correlated with NLR in both of CRT patients and FP patients. In patients treated with CRT, a partial response was significantly higher in patients with a low NLR and with progressive disease compared to those with a high NLR. In patients treated with FP, a partial response was also significantly higher in patients with a low NLR and with progressive disease compared to those with a high NLR. The overall survival of patients with CRT and FP were both significantly worse in patients with a high NLR than in those with a low NLR. NLR may serve as a useful marker of the tumor response, immune suppression, malnutrition and prognosis upon CRT or FP in patients with locally advanced or metastatic ESCC.

Keywords: esophageal squamous cell carcinoma; inflammation; neutrophil-to-lymphocyte ratio; nutrition.

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Figures

Figure 1.
Figure 1.
Correlation of NLR with nutritional parameters in patients receiving chemoradiation therapy. NLR, neutrophil to lymphocyte ratio; PA, prealbumin; RBP, retinol binding protein.
Figure 2.
Figure 2.
Correlation of NLR with (A) prealbumin and (B) retinol binding protein in patients receiving a combination of 5-fluorouracil and cisplatin. NLR, neutrophil to lymphocyte ratio; PA, prealbumin; RBP, retinol binding protein.
Figure 3.
Figure 3.
Correlation of NLR with (A) inflammation and (B) cell-mediated immune function in patients received chemoradiation therapy. CRP, C reactive protein; SI, stimulation index; NLR, neutrophil to lymphocyte ratio.
Figure 4.
Figure 4.
Correlation of NLR with (A) inflammation and (B) cell-mediated immune function in patients received a combination of 5-fluorouracil and cisplatin. NLR, neutrophil to lymphocyte ratio; CRP, C reactive protein; SI, stimulation index.
Figure 5.
Figure 5.
Kaplan-Meier curves for patients with low and high neutrophil to lymphocyte ratio. NLR, neutrophil to lymphocyte ratio.
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