doi: 10.1126/science.2868526.
Gonadotroph-specific expression of metallothionein fusion genes in pituitaries of transgenic mice
- PMID: 2868526
- DOI: 10.1126/science.2868526
Item in Clipboard
Gonadotroph-specific expression of metallothionein fusion genes in pituitaries of transgenic mice
Science.
.
Abstract
Transgenic mice expressing a metallothionein-somatostatin fusion gene contain high concentrations of somatostatin in the anterior pituitary gland, a tissue that does not normally produce somatostatin. Immunoreactive somatostatin within the anterior pituitaries was found exclusively within gonadotrophs. Similarly, a metallothionein-human growth-hormone fusion gene was also expressed selectively in gonadotrophs. It is proposed that sequences common to the two fusion genes are responsible for the gonadotroph-specific expression.
Similar articles
-
Somatostatin is targeted to the regulated secretory pathway of gonadotrophs in transgenic mice expressing a metallothionein-somatostatin gene.J Biol Chem. 1986 Dec 5;261(34):16260-3. J Biol Chem. 1986. PMID: 2877985
-
Tissue-specific posttranslational processing of pre-prosomatostatin encoded by a metallothionein-somatostatin fusion gene in transgenic mice.Cell. 1985 May;41(1):211-9. doi: 10.1016/0092-8674(85)90075-3. Cell. 1985. PMID: 2859927
-
Cryptic human growth hormone gene sequences direct gonadotroph-specific expression in transgenic mice.Mol Endocrinol. 1989 Dec;3(12):2028-33. doi: 10.1210/mend-3-12-2028. Mol Endocrinol. 1989. PMID: 2576462
-
Metallothionein-human GH fusion genes stimulate growth of mice.Science. 1983 Nov 18;222(4625):809-14. doi: 10.1126/science.6356363. Science. 1983. PMID: 6356363 Review.
-
Introduction of genes into the germ line of animals.Harvey Lect. 1984-1985;80:1-38. Harvey Lect. 1984. PMID: 6400653 Free PMC article. Review. No abstract available.
Cited by
-
Processing and proliferative effects of human progastrin in transgenic mice.J Clin Invest. 1996 Oct 15;98(8):1918-29. doi: 10.1172/JCI118993. J Clin Invest. 1996. PMID: 8878444 Free PMC article.
-
A milk protein gene promoter directs the expression of human tissue plasminogen activator cDNA to the mammary gland in transgenic mice.Proc Natl Acad Sci U S A. 1988 Aug;85(16):5874-8. doi: 10.1073/pnas.85.16.5874. Proc Natl Acad Sci U S A. 1988. PMID: 2842753 Free PMC article.
-
A Mup promoter-thymidine kinase reporter gene shows relaxed tissue-specific expression and confers male sterility upon transgenic mice.Mol Cell Biol. 1988 Nov;8(11):4821-8. doi: 10.1128/mcb.8.11.4821-4828.1988. Mol Cell Biol. 1988. PMID: 2850469 Free PMC article.
-
Germ-line transformation of mice.Annu Rev Genet. 1986;20:465-99. doi: 10.1146/annurev.ge.20.120186.002341. Annu Rev Genet. 1986. PMID: 3545063 Free PMC article. Review. No abstract available.
-
Differential regulation of rat beta-casein-chloramphenicol acetyltransferase fusion gene expression in transgenic mice.Mol Cell Biol. 1989 Feb;9(2):560-5. doi: 10.1128/mcb.9.2.560-565.1989. Mol Cell Biol. 1989. PMID: 2710117 Free PMC article.
Publication types
MeSH terms
Substances
Grants and funding
etc
LinkOut - more resources
Full Text Sources
Other Literature Sources
