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. 2017:977:313-318.
doi: 10.1007/978-3-319-55231-6_41.

Measurement of pO2 in a Pre-clinical Model of Rabbit Tumor Using OxyChip, a Paramagnetic Oxygen Sensor

H Hou  1 , N Khan  1 , P Kuppusamy  2
Affiliations

Measurement of pO2 in a Pre-clinical Model of Rabbit Tumor Using OxyChip, a Paramagnetic Oxygen Sensor

H Hou et al. Adv Exp Med Biol. 2017.

Abstract

The objective of this work was to establish a novel and robust technology, based on electron paramagnetic resonance (EPR) oximetry, as a practical tool for measurement of tumor oxygen. Previously, we have reported on the development of oxygen-sensing paramagnetic crystals (LiNc-BuO) encapsulated in a biocompatible polymer, called OxyChip. In this report we present our recent data on the use of OxyChip for pO2 measurements in the tumor of a pre-clinical, large-animal rabbit model. The results establish that OxyChip is capable of noninvasive and repeated measurement of pO2 in a large animal model.

Keywords: Electron paramagnetic resonance (EPR); Oximetry; OxyChip; Partial pressure of oxygen (pO2); Rabbit; VX2 tumor.

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