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Review
. 2017 Jul 7;4(7):57.
doi: 10.3390/children4070057.

The Association between Non-Alcoholic Fatty Liver Disease and Cardiovascular Risk in Children

Affiliations
Review

The Association between Non-Alcoholic Fatty Liver Disease and Cardiovascular Risk in Children

Anna Di Sessa et al. Children (Basel). .

Abstract

The rising prevalence of childhood obesity in the past decades has made Non-Alcoholic Fatty Liver Disease (NAFLD) the most common cause of pediatric chronic liver disease worldwide. Currently, a growing body of evidence links NAFLD with cardiovascular disease (CVD) even at an early age. Data on the pediatric population have shown that NAFLD could represent an independent risk factor not only for cardiovascular events but also for early subclinical abnormalities in myocardial structure and function. Briefly, we review the current knowledge regarding the relationship between pediatric NAFLD and cardiovascular risk in an attempt to clarify our understanding of NAFLD as a possible cardiovascular risk factor in childhood.

Keywords: Non-Alcoholic Fatty Liver Disease; abnormalities; atherosclerosis; cardiac; cardiovascular; diseases; risk.

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Conflict of interest statement

The authors declare no conflict of interest.

References

    1. Loomba R., Sirlin C.B., Schwimmer J.B., Lavine J.E. Advances in pediatric nonalcoholic fatty liver disease. Hepatology. 2009;50:1282–1293. doi: 10.1002/hep.23119. - DOI - PMC - PubMed
    1. Marzuillo P., Grandone A., Perrone L., Miraglia del Giudice E. Understanding the pathophysiological mechanisms in the pediatric non-alcoholic fatty liver disease: The role of genetics. World J. Hepatol. 2015;7:1439–1443. doi: 10.4254/wjh.v7.i11.1439. - DOI - PMC - PubMed
    1. Feldstein A.E., Charatcharoenwitthaya P., Treeprasertsuk S., Benson J.T., Enders F.B., Angulo P. The natural history of nonalcoholic fatty liver disease in children: A follow-up study for up to 20 years. Gut. 2009;58:1538–1544. doi: 10.1136/gut.2008.171280. - DOI - PMC - PubMed
    1. Pacifico L., Cantisani V., Ricci P., Osborn J.F., Schiavo E., Anania C., Ferrara E., Dvisic G., Chiesa C. Nonalcoholic fatty liver disease and carotid atherosclerosis in children. Pediatr. Res. 2008;63:423–427. doi: 10.1203/PDR.0b013e318165b8e7. - DOI - PubMed
    1. Di Sessa A., Umano G.R., Miraglia del Giudice E., Santoro N. From the liver to the heart: Cardiac dysfunction in obese children with non-alcoholic fatty liver disease. World J. Hepatol. 2017;9:69–73. doi: 10.4254/wjh.v9.i2.69. - DOI - PMC - PubMed

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