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. 2018 Feb 15;197(4):524-528.
doi: 10.1164/rccm.201706-1097LE.

Metagenomic Sequencing Detects Respiratory Pathogens in Hematopoietic Cellular Transplant Patients

Charles Langelier  1 , Matt S Zinter  1 , Katrina Kalantar  1 , Gregory A Yanik  2 , Stephanie Christenson  1 , Brian O'Donovan  1 , Corin White  1 , Michael Wilson  1 , Anil Sapru  1 , Christopher C Dvorak  1 , Steve Miller  1 , Charles Y Chiu  1 , Joseph L DeRisi  1   3
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Metagenomic Sequencing Detects Respiratory Pathogens in Hematopoietic Cellular Transplant Patients

Charles Langelier et al. Am J Respir Crit Care Med. .
No abstract available

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Figures

Figure 1.
Figure 1.
Bronchoalveolar lavage microbial diversity is inversely associated with presence of a transcriptionally active respiratory pathogen. Each data point represents a single patient (Pt) for whom the Simpson diversity index is plotted on the y-axis. Subjects are grouped according to confirmed pathogen (red diamonds) vs. unlikely or uncertain pathogen (black circles). Patients with confirmed pathogens had significantly lower diversity relative to patients with only microbes of unlikely pathogenicity (median, 0.34 [interquartile range, 0.15–0.64; n = 6] vs. 0.92 [interquartile range, 0.86–0.93; n = 10]; P = 0.017).
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