Metabolomics and fetal alcohol spectrum disorder

Abstract

Fetal alcohol spectrum disorder (FASD) is a major public health issue that encompass an array of physical, neurological, and behavioral effects due to alcohol consumption during pregnancy. The classical biomarkers of FASD that are currently used lack sensitivity and specificity, and as such there is an opportunity through the use of novel metabolomics analysis to identify new biomarkers to identify those at risk for FASD, which could more effectively aid in early intervention. The focus of this minireview is to identify current work that is being done in the field of metabolomics in FASD in utero, and to highlight promising metabolites that could act as biomarkers in the future. We will conclude with suggestions for further research, as there is a large gap of knowledge in this particular area of metabolomics.

Keywords: ethanol; exposition prénatale à l’alcool; fetal alcohol spectrum disorder; fetal alcohol syndrome; metabolomics; métabolomique; prenatal alcohol exposure; syndrome d’alcoolisation fœtale; troubles du spectre de l’alcoolisation fœtale; éthanol.