Modeling the Glomerular Filtration Barrier: Are You Kidney-ing Me?

Paola Romagnani¹, Laura Lasagni²

Affiliations

¹ Excellence Centre for Research, Transfer and High Education for the development of DE NOVO Therapies (DENOTHE) and Department of Biomedical, Experimental and Clinical Sciences 'Mario Serio', University of Florence, 50121 Florence, Italy; Pediatric Nephrology Unit, Meyer Children's Hospital, University of Florence, 50139 Florence, Italy. Electronic address: paola.romagnani@unifi.it.
² Excellence Centre for Research, Transfer and High Education for the development of DE NOVO Therapies (DENOTHE) and Department of Biomedical, Experimental and Clinical Sciences 'Mario Serio', University of Florence, 50121 Florence, Italy.

PMID: 28686869
DOI: 10.1016/j.stem.2017.06.008

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Modeling the Glomerular Filtration Barrier: Are You Kidney-ing Me?

Paola Romagnani et al. Cell Stem Cell. 2017.

Free article

. 2017 Jul 6;21(1):7-9.

doi: 10.1016/j.stem.2017.06.008.

Authors

Paola Romagnani¹, Laura Lasagni²

Affiliations

¹ Excellence Centre for Research, Transfer and High Education for the development of DE NOVO Therapies (DENOTHE) and Department of Biomedical, Experimental and Clinical Sciences 'Mario Serio', University of Florence, 50121 Florence, Italy; Pediatric Nephrology Unit, Meyer Children's Hospital, University of Florence, 50139 Florence, Italy. Electronic address: paola.romagnani@unifi.it.
² Excellence Centre for Research, Transfer and High Education for the development of DE NOVO Therapies (DENOTHE) and Department of Biomedical, Experimental and Clinical Sciences 'Mario Serio', University of Florence, 50121 Florence, Italy.

PMID: 28686869
DOI: 10.1016/j.stem.2017.06.008

Abstract

Podocyte depletion drives kidney disease and kidney failure progression, but podocyte complexity at the glomerular filtration barrier is difficult to model in vitro. In Nature Biomedical Engineering, Musah et al. (2017) developed a multifluidic device with iPS-derived podocytes mimicking a functional glomerular filtration barrier that elevates standards for modeling glomerular diseases.

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Mature induced-pluripotent-stem-cell-derived human podocytes reconstitute kidney glomerular-capillary-wall function on a chip.
Musah S, Mammoto A, Ferrante TC, Jeanty SSF, Hirano-Kobayashi M, Mammoto T, Roberts K, Chung S, Novak R, Ingram M, Fatanat-Didar T, Koshy S, Weaver JC, Church GM, Ingber DE. Musah S, et al. Nat Biomed Eng. 2017;1:0069. doi: 10.1038/s41551-017-0069. Epub 2017 May 10. Nat Biomed Eng. 2017. PMID: 29038743 Free PMC article.

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Modeling the Glomerular Filtration Barrier: Are You Kidney-ing Me?

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Modeling the Glomerular Filtration Barrier: Are You Kidney-ing Me?

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Abstract

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Medical