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Comment
. 2017 Jul 6;21(1):9-11.
doi: 10.1016/j.stem.2017.06.002.

Retinoic Acid Puts Hematopoietic Stem Cells Back To Sleep

Alexandra Rundberg Nilsson  1 , Cornelis Jan Pronk  2
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Comment

Retinoic Acid Puts Hematopoietic Stem Cells Back To Sleep

Alexandra Rundberg Nilsson et al. Cell Stem Cell. .
Free article

Abstract

Dormant hematopoietic stem cells (dHSCs) display superior serial reconstitution capacity compared to active HSCs, although their role in normal hematopoiesis has not been thoroughly investigated. Recently in Cell, Cabezas-Wallscheid et al. (2017) demonstrate involvement of retinoic acid signaling in murine dHSCs for preservation of the HSC pool.

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  • Vitamin A-Retinoic Acid Signaling Regulates Hematopoietic Stem Cell Dormancy.
    Cabezas-Wallscheid N, Buettner F, Sommerkamp P, Klimmeck D, Ladel L, Thalheimer FB, Pastor-Flores D, Roma LP, Renders S, Zeisberger P, Przybylla A, Schönberger K, Scognamiglio R, Altamura S, Florian CM, Fawaz M, Vonficht D, Tesio M, Collier P, Pavlinic D, Geiger H, Schroeder T, Benes V, Dick TP, Rieger MA, Stegle O, Trumpp A. Cabezas-Wallscheid N, et al. Cell. 2017 May 18;169(5):807-823.e19. doi: 10.1016/j.cell.2017.04.018. Epub 2017 May 4. Cell. 2017. PMID: 28479188

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