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Case Reports
. 2017 Jul 6:2017:bcr2017219491.
doi: 10.1136/bcr-2017-219491.

Isolated insulin-derived amyloidoma of the breast

Jonathan Mark Mayhew  1 , Tanya Alan  1 , Venu Kalidindi  1 , Tasha A K Gandamihardja  1
Affiliations
Case Reports

Isolated insulin-derived amyloidoma of the breast

Jonathan Mark Mayhew et al. BMJ Case Rep. .

Abstract

Isolated amyloidomas derived from insulin are extremely rare, and there is only one reported case to date of insulin-derived amyloidoma in the breast.We present the case of a 36-year-old woman reporting a lump in the right breast. It was clinically assessed as a probable fibroadenoma but was removed surgically given the size of the lesion. On histological analysis, the lesion had features consistent with amyloid. Further investigations showed the amyloid to be derived from insulin. The lump was removed in its entirety, and the patient made a full recovery.

Keywords: Breast surgery; Pathology.

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Conflict of interest statement

Competing interests: None declared.

Figures

Figure 1
Figure 1
Extensive deposition of amorphous eosinophilic material (H&E ×10 magnification).
Figure 2
Figure 2
Reticulin special stain showing fibrillar nature of amyloid deposits (H&E ×20 magnification).
Figure 3
Figure 3
Congo Red special stain showing orange red colouration to band-like amyloid deposits (×20 magnification).
Figure 4
Figure 4
Same area as figure 3 under cross-polarised light exhibiting apple green birefringence within band-like amyloid deposits (×20 magnification).
See this image and copyright information in PMC

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