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. 2017 Nov;143(11):2283-2290.
doi: 10.1007/s00432-017-2473-8. Epub 2017 Jul 8.

Sex-specific incidence of EGFR mutation and its association with age and obesity in lung adenocarcinomas: a retrospective analysis

Hye-Ryoun Kim  1 , Seo Yun Kim  1 , Cheol Hyeon Kim  1 , Sung Hyun Yang  1 , Jae Cheol Lee  2 , Chang-Min Choi  2 , Im Il Na  3
Affiliations

Sex-specific incidence of EGFR mutation and its association with age and obesity in lung adenocarcinomas: a retrospective analysis

Hye-Ryoun Kim et al. J Cancer Res Clin Oncol. 2017 Nov.

Abstract

Purpose: Age and obesity are well-known risk factors for various cancers, but the potential roles of age and obesity in lung cancer, especially in those with activating EGFR mutations, have not been thoroughly evaluated. The aim of this retrospective study is to evaluate the associations between the sex-specific incidence of EGFR mutations and age and obesity.

Methods: We conducted a retrospective study based on the data from 1378 lung adenocarcinoma cases. The degree of obesity was categorized by body mass index (BMI). The associations between EGFR mutational status and clinical factors, including stage, smoking history, age group (≤45 years, 46-55, 56-65 and >65), and BMI group (<18.5 kg/m2, 18.5-22.9, 23.0-24.9 and ≥25.0) were analyzed using logistic regression models for each sex.

Results: In men, the incidence of EGFR mutation was inversely associated with age (adjusted odds ratio [OR] for age group = 0.76, p-trend = 0.003) and positively associated with obesity (adjusted OR for BMI group = 1.23, p-trend = 0.04). In contrast, in women, the incidence of EGFR mutation was positively associated with age (adjusted OR for age group = 1.19, p-trend = 0.02). However, the incidence of EGFR mutation was not statistically associated with obesity (adjusted OR for BMI group = 1.03, p-trend = 0.76).

Conclusions: Our data suggests that age and obesity may contribute to the sex-specific incidence of EGFR mutation in lung adenocarcinoma in different manners.

Keywords: Age; EGFR mutation; Obesity; Sex.

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Conflict of interest statement

The authors declare that they have no conflict of interest.

Figures

Fig. 1
Fig. 1
EGFR mutation rates by age group
Fig. 2
Fig. 2
EGFR mutation rates by BMI group
See this image and copyright information in PMC

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