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Review
. 2017 Sep-Oct;19(9-10):449-458.
doi: 10.1016/j.micinf.2017.06.005. Epub 2017 Jul 6.

Regulation and functions of inflammasome-mediated cytokines in Helicobacter pylori infection

Le Son Tran  1 , Michelle Chonwerawong  1 , Richard L Ferrero  2
Affiliations
Free article
Review

Regulation and functions of inflammasome-mediated cytokines in Helicobacter pylori infection

Le Son Tran et al. Microbes Infect. 2017 Sep-Oct.
Free article

Abstract

Persistent stomach infection with Helicobacter pylori causes chronic mucosal inflammation (gastritis), which is widely recognized as an essential precursor to gastric cancer. The IL-1 interleukin family cytokines IL-1β and IL-18 have emerged as central mediators of mucosal inflammation. Here, we review the regulation and functions of these cytokines in H. pylori-induced inflammation and carcinogenesis.

Keywords: Gastric cancer; Helicobacter pylori; IL-18; IL-1β; Inflammasome; NOD-like receptors.

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