Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2018 Feb;15(2):85-87.
doi: 10.1038/cmi.2017.56. Epub 2017 Jul 10.

Dietary therapy may be sufficient for type 1 diabetes treatment

Affiliations
Comment

Dietary therapy may be sufficient for type 1 diabetes treatment

Shuoyang Liu et al. Cell Mol Immunol. 2018 Feb.
No abstract available

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Complete inhibition of diabetes in non-obese diabetic (NOD) mice through combined acetate and butyrate ingestion. As the major components of short-chain fatty acids (SCFAs), acetate potently inhibits autoreactive T cells, whereas butyrate promotes Treg activity. The combination of acetate and butyrate completely protect NOD mice from the development of the disease. This effect of acetate and butyrate may be therapeutically harnessed in the prevention and treatment of T1D and other autoimmune diseases in human.

Comment on

References

    1. Shi Y, Mu L. An expanding stage for commensal microbes in host immune regulation. Cell Mol Immunol 2017; 14: 339–348. - PMC - PubMed
    1. Sivaprakasam S, Prasad PD, Singh N. Benefits of short-chain fatty acids and their receptors in inflammation and carcinogenesis. Pharmacol Ther 2016; 164: 144–151. - PMC - PubMed
    1. Marino E, Richards JL, McLeod KH, Stanley D, Yap YA, Knight J et al. Gut microbial metabolites limit the frequency of autoimmune T cells and protect against type 1 diabetes. Nat Immunol 2017; 18: 552–562. - PubMed
    1. Altobelli E, Petrocelli R, Verrotti A, Chiarelli F, Marziliano C. Genetic and environmental factors affect the onset of type 1 diabetes mellitus. Pediatr Diabet 2016; 17: 559–566. - PubMed
    1. Zheng Y, Wang Z, Zhou Z. miRNAs: novel regulators of autoimmunity-mediated pancreatic beta-cell destruction in type 1 diabetes. Cell Mol Immunol 2017; 14: 488–496. - PMC - PubMed

Publication types