Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2018 Jan;15(1):5-7.
doi: 10.1038/cmi.2017.55. Epub 2017 Jul 10.

Long noncoding RNA lncKdm2b: A critical player in the maintenance of group 3 innate lymphoid cells

Can-Jie Guo  1   2 , Weici Zhang  2 , M Eric Gershwin  2
Affiliations
Comment

Long noncoding RNA lncKdm2b: A critical player in the maintenance of group 3 innate lymphoid cells

Can-Jie Guo et al. Cell Mol Immunol. 2018 Jan.
No abstract available

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
A novel mechanism of lncKdm2b-mediated transcriptional regulation implicated in maintaining ILC3 proliferation and function. (a) lncKdm2b is required for the activation of Zfp292 expression. lncKdm2b directly binds to Satb1, which subsequently recruits the NURF complex comprising Bptf and Snf2l. This RNA/protein complex further binds to the Zfp292 promoter to activate Zfp292 expression in ILC3s of wild-type mice. (b) Loss of lncKdm2b abrogates the recruitment of Satb1 and NURF complex comprising Bptf and Snf2l on the Zfp292 promoter, resulting in impaired number and function of ILC3s. Consequently, Vav-Cre-directed lncKdm2b conditional knockout mice are susceptible to Citrobacter rodentium infection compared to wild-type mice.
See this image and copyright information in PMC

Comment on

References

    1. Klose CS, Artis D. Innate lymphoid cells as regulators of immunity, inflammation and tissue homeostasis. Nat Immunol 2016; 17: 765–774. - PubMed
    1. Kwon B. Regulatory roles of dermal type 2 innate lymphoid cells. Cell Mol Immunol 2013; 10: 453–455. - PMC - PubMed
    1. Croxatto D, Micheletti A, Montaldo E, Orecchia P, Loiacono F, Canegallo F et al. Group 3 innate lymphoid cells regulate neutrophil migration and function in human decidua. Mucosal Immunol 2016; 9: 1372–1383. - PubMed
    1. Melo-Gonzalez F, Hepworth MR. Functional and phenotypic heterogeneity of group 3 innate lymphoid cells. Immunology 2017; 150: 265–275. - PMC - PubMed
    1. Tajuddin SM, Schick UM, Eicher JD, Chami N, Giri A, Brody JA et al. Large-scale exome-wide association analysis identifies loci for white blood cell traits and pleiotropy with immune-mediated diseases. Am J Hum Genet 2016; 99: 22–39. - PMC - PubMed

MeSH terms

Substances

LinkOut - more resources