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. 2017 Nov;30(6):464-472.
doi: 10.1111/sdi.12626. Epub 2017 Jul 9.

Definitions of intradialytic hypotension

Magdalene M Assimon  1   2 , Jennifer E Flythe  1   3
Affiliations

Definitions of intradialytic hypotension

Magdalene M Assimon et al. Semin Dial. 2017 Nov.

Abstract

Intradialytic hypotension (IDH) is a common and often distressful complication of hemodialysis. However, despite its clinical significance, there is no consensus, evidence-based medical definition for the condition. Over the years, numerous definitions have been implemented in both the clinical and research settings. Definition inconsistencies have hindered data synthesis and the development of evidence-based guidelines for the prevention and treatment of IDH, as well as prevented accurate estimation of the population burden of IDH and patient risk assessment. Most existing IDH definitions are comprised of one or more of the following components: (1) intradialytic BP criteria (requisite BP declines or minimum BP thresholds), (2) the provision of interventions aimed at restoring effective arterial volume, and/or (3) patient-reported symptoms. Remarkably, there are insufficient data to inform IDH definition construction, and it remains unknown if a single, universal definition can adequately capture the condition across patient subgroups, and in clinical and research settings.

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Figures

Figure 1
Figure 1
Potential intradialytic hypotension definition components. Abbreviations: BP, blood pressure
Figure 2
Figure 2
Differences in mean- and frequency-based intradialytic hypotension definitions. The figure depicts the application of mean and frequency-based intradialytic hypotension definitions in a 30-day exposure assessment period (12 hemodialysis treatments) in a single, hypothetical individual. Abbreviations: IDH, intradialytic hypotension; SBP, systolic blood pressure
See this image and copyright information in PMC

References

    1. Oxford English Dictionary. define, v. Oxford University Press; 2016.
    1. Drukker W, Parsons FM, Maher JF. Replacement of renal function by dialysis : a textbook of dialysis. 2. Boston Hingham, MA: M. Nijhoff ; distributors for the U.S. and Canada, Kluwer Boston, Inc; 1983.
    1. Flythe JE, Xue H, Lynch KE, Curhan GC, Brunelli SM. Association of mortality risk with various definitions of intradialytic hypotension. J Am Soc Nephrol. 2015;26(3):724–734. - PMC - PubMed
    1. Sands JJ, Usvyat LA, Sullivan T, et al. Intradialytic hypotension: frequency, sources of variation and correlation with clinical outcome. Hemodial Int. 2014;18(2):415–422. - PubMed
    1. Caplin B, Kumar S, Davenport A. Patients’ perspective of haemodialysis-associated symptoms. Nephrol Dial Transplant. 2011;26(8):2656–2663. - PubMed

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