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. 2018 Feb;32(3):341-345.
doi: 10.1080/14786419.2017.1350672. Epub 2017 Jul 10.

Chemical constituents from the leaves of Pinus dalatensis Ferré

Nguyen Hoang Sa  1   2 , Nguyen Thanh Tam  1   3 , Nguyen Thi Hoang Anh  1   3 , Tran Duc Quan  3 , Dao Duc Thien  3 , Dinh Thi Phong  4 , Tran Van Sung  1 , Trinh Thi Thuy  1   3
Affiliations

Chemical constituents from the leaves of Pinus dalatensis Ferré

Nguyen Hoang Sa et al. Nat Prod Res. 2018 Feb.

Abstract

A phytochemical study of n-hexane and ethyl acetate extracts of Pinus dalatensis Ferré leaves led to the isolation of 11 compounds, including one caryolane sesquiterpenoid (1), five labdane diterpenoids (2, 3, 4, 5, 6), one serratane triterpenoid (7), one diacylated flavonoid glucoside (8), one stilbenoid (9) and two sterols (10, 11). The structural characterisation of the isolated compounds was elucidated by spectroscopic data and comparison with the literature report on the chemical constituents from Pinus dalatensis Ferré. Futhermore, three compounds 1, 4 and 6 were obtained for the first time from the genus Pinus. Besides, compounds (2, 3, 5, 8, 9) were also subjected to cytotoxicity effect on SK-LU-1, MCF-7 and Hep-G2 cell lines, but only compound 9 expressed activities with IC50 values of 141.22, 127.81 and 166.84 μM, respectively.

Keywords: Pinus dalatensis Ferré; caryolane; labdane; pinusolidic acid.

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