Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2017 Sep/Oct;28(5):299-307.
doi: 10.1097/DER.0000000000000304.

Fragrances Categorized According to Relative Human Skin Sensitization Potency

Anne Marie Api  1 , Rahul Parakhia, Devin OʼBrien, David A Basketter
Affiliations

Fragrances Categorized According to Relative Human Skin Sensitization Potency

Anne Marie Api et al. Dermatitis. 2017 Sep/Oct.

Abstract

Background: The development of non-animal alternatives for skin sensitization potency prediction is dependent upon the availability of a sufficient dataset whose human potency is well characterized. Previously, establishment of basic categorization criteria for 6 defined potency categories, allowed 131 substances to be allocated into them entirely on the basis of human information.

Objectives: To supplement the original dataset with an extended range of fragrance substances.

Methods: A more fully described version of the original criteria was used to assess 89 fragrance chemicals, allowing their allocation into one of the 6 potency categories.

Results: None of the fragrance substances were assigned to the most potent group, category 1, whereas 11 were category 2, 22 were category 3, 37 were category 4, and 19 were category 5. Although none were identified as non-sensitizing, note that substances in category 5 also do not pass the threshold for regulatory classification.

Conclusions: The combined datasets of >200 substances placed into potency categories solely on the basis of human data provides an essential resource for the elaboration and evaluation of predictive non-animal methods.

PubMed Disclaimer

Conflict of interest statement

The authors have no funding or conflicts of interest to declare.

Figures

Figure 1
Figure 1
How the potency categories are populated. This figure combines the information from the first publication with the present data to show the number of substances placed into each of the 6 categories.
See this image and copyright information in PMC

References

    1. Ballantyne B, Myers T, Syversen T. General and Applied Toxicology. 3rd ed Chichester, UK: Wiley; 2009.
    1. Thyssen JP, Giménez-Arnau E, Lepoittevin JP, et al. The critical review of methodologies and approaches to assess the inherent skin sensitization potential (skin allergies) of chemicals. Parts I and II. Contact Dermatitis 2012;66(Suppl 1):11–24. - PubMed
    1. Kimber I, Basketter DA. Contact sensitization: a new approach to risk assessment. Hum Ecol Risk Assess 1997;3:385–395.
    1. Basketter DA, Lea LJ, Cooper K, et al. A comparison of statistical approaches to the derivation of EC3 values from local lymph node assay dose responses. J Appl Toxicol 1999;19:261–266. - PubMed
    1. Basketter DA, Gerberick F, Kimber I. The local lymph node assay EC3 value: status of validation. Contact Dermatitis 2007;57:70–75. - PubMed

LinkOut - more resources