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Review
. 2017 Aug;23(8):721-736.
doi: 10.1016/j.molmed.2017.06.001. Epub 2017 Jul 7.

miRNAs in B Cell Development and Lymphomagenesis

Maryaline Coffre  1 , Sergei B Koralov  2
Affiliations
Review

miRNAs in B Cell Development and Lymphomagenesis

Maryaline Coffre et al. Trends Mol Med. 2017 Aug.

Abstract

B lymphocytes are essential for an efficient immune response against a variety of pathogens. A large fraction of hematologic malignancies is of B cell origin, suggesting that the development and activation of B cells need to be tightly regulated. In recent years, increasing evidence has emerged demonstrating that microRNAs (miRNAs) - a class of non-coding RNAs that control gene expression - are involved in the regulation of B cell development and function. We provide here an overview of the current knowledge on the role of miRNAs and their relevant targets in B cell development, B cell activation, and B cell malignant transformation.

Keywords: B cell development; B cell function; B cell lymphomas; miRNAs.

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Figures

Key Figure, Figure 1
Key Figure, Figure 1
miRNAs Can Regulate All Stages of Mammalian B Cell Development and Activation
See this image and copyright information in PMC

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