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. 1986 Jan 30;63(3):225-30.
doi: 10.1016/0304-3940(86)90360-5.

Excitatory amino acid receptors in hippocampal neurons: kainate fails to desensitize them

N I Kiskin, O A Krishtal, Tsyndrenko AYa

Excitatory amino acid receptors in hippocampal neurons: kainate fails to desensitize them

N I Kiskin et al. Neurosci Lett. .

Abstract

The excitatory responses to L-glutamate (L-Glu), quisqualate (QA) and kainate (KA) have been investigated in isolated pyramidal cells from rat hippocampus using intracellular perfusion and concentration clamp techniques. The responses to L-Glu and QA demonstrated rapid desensitization and complete cross-desensitization, while KA produced a non-desensitizing response. The activation of KA response was determined by the level of desensitization induced by L-Glu or QA pretreatment. It is concluded that QA, KA and L-Glu activate the same excitatory receptors with apparent Kd values of 9.3 X 10(-5) M, 5.0 X 10(-4) M and 1.1 X 10(-3) M, respectively.

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