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. 2017 Mar;5(3):11.
doi: 10.1007/s40134-017-0204-1. Epub 2017 Feb 14.

Susceptibility-Based Neuroimaging: Standard Methods, Clinical Applications, and Future Directions

Salil Soman  1 , Jose A Bregni  2 , Berkin Bilgic  3 , Ursula Nemec  4 , Audrey Fan  5 , Zhe Liu  6 , Robert L Barry  7 , Jiang Du  8 , Keith Main  9 , Jerome Yesavage  10 , Maheen M Adamson  11 , Michael Moseley  12 , Yi Wang  13
Affiliations

Susceptibility-Based Neuroimaging: Standard Methods, Clinical Applications, and Future Directions

Salil Soman et al. Curr Radiol Rep. 2017 Mar.

Abstract

The evaluation of neuropathologies using MRI methods that leverage tissue susceptibility have become standard practice, especially to detect blood products or mineralization. Additionally, emerging MRI techniques have the ability to provide new information based on tissue susceptibility properties in a robust and quantitative manner. This paper discusses these advanced susceptibility imaging techniques and their clinical applications.

Keywords: MRI; neuroimaging; neuropathologies; susceptibility imaging techniques.

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Conflict of interest statement

Conflict of Interest Salil Soman, Jose A. Bregni, Berkin Bilgic, Ursula Nemec, Zhe Liu, Robert L. Barry, Jiang Du, Keith Main, Jerome Yesavage, Maheen M Adamson, and Michael Moseley each declare no potential conflicts of interest.

Figures

Figure 1
Figure 1
3D T2* weighted multi echo GRE images obtained at 3T. (A) TE=14, (B)TE=33, (C) TE=52. Note that with increasing TE, the T2* contrast increases, but artifacts due to field inhomogeneity also increase.
Figure 2
Figure 2
QSM MEDI and QSM TFI images on same subject, acquired at 3T. (A) QSM TFI (B)QSM MEDI. Note that skull anatomic landmarks (solid arrows) and brain tissue (dashed arrows) are preserved in the mask free TFI method, compared to MEDI on these images.
Figure 3
Figure 3
QSM Venous Oxygenation Mapping. (A) Original QSM map in healthy volunteer with χ > 0.15 threshold, (B) Surface renderings of vessel and (C) Calculated Mixed Venous Oxygen Saturation measurements (SvO2). SSS=superior sagittal sinus, SS=straight sinus, TS=transverse sinus, ISS=inferior sagittal sinus, SAV=superficial anastomic vein.
Figure 4
Figure 4
7T resting state functional connectivity maps of cervical spinal cord. Functional connectivity demonstration between (A) left and right ventral (motor) horns and (B) left and right dorsal (sensory) horns of spinal cord gray matter. (C) Spinal cord gross anatomical arrangement.
Figure 5
Figure 5
Brain IR UTE MRI at varying inversion times (TI) (TR = 300, TI = 85/90/95/100/110/120 ms). Contrast between cortical bone (solid arrows) and marrow (dashed arrows) is greatest at (A) TI-85ms and least at (B) TI-120ms.
See this image and copyright information in PMC

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