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. 2017 Sep;10(5):1057-1061.
doi: 10.1111/1751-7915.12778. Epub 2017 Jul 11.

Sustainable therapies by engineered bacteria

Beatriz Álvarez  1 , Luis Ángel Fernández  1
Affiliations

Sustainable therapies by engineered bacteria

Beatriz Álvarez et al. Microb Biotechnol. 2017 Sep.

Abstract

The controlled in situ delivery of biologics (e.g. enzymes, cytokines, antibodies) by engineered bacteria of our microbiome will allow the sustainable production of these complex and expensive drugs locally in the human body, overcoming many of the technical and economical barriers currently associated with the global use of these potent medicines. We provide examples showing how engineered bacteria can be effective treatments against multiple pathologies, including autoimmune and inflammatory diseases, metabolic disorders, diabetes, obesity, infectious diseases and cancer, hence contributing to achieve the Global Sustainable Goal 3: ensure healthy lives and promote well-being for all at all ages.

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References

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