Lipid Droplets Guard Mitochondria during Autophagy
- PMID: 28697329
- DOI: 10.1016/j.devcel.2017.06.018
Lipid Droplets Guard Mitochondria during Autophagy
Abstract
In this issue of Developmental Cell, Nguyen et al. (2017) show that lipid droplets serve a dual purpose during starvation. First, they act as an energy source by supplying fatty acids for mitochondrial β oxidation. Second, they sequester toxic lipids that arise during autophagic degradation of membranous organelles, thereby protecting mitochondria.
Copyright © 2017 Elsevier Inc. All rights reserved.
Comment on
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DGAT1-Dependent Lipid Droplet Biogenesis Protects Mitochondrial Function during Starvation-Induced Autophagy.Dev Cell. 2017 Jul 10;42(1):9-21.e5. doi: 10.1016/j.devcel.2017.06.003. Dev Cell. 2017. PMID: 28697336 Free PMC article.
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