Comment

. 2017 Jul 10;42(1):7-8.

doi: 10.1016/j.devcel.2017.06.017.

Heart Regeneration 4.0: Matrix Medicine

Elif Eroglu¹, Kenneth R Chien²

Affiliations

¹ Department of Cell and Molecular Biology, Karolinska Institute, Stockholm, SE 171 77.
² Department of Cell and Molecular Biology, Karolinska Institute, Stockholm, SE 171 77; Department of Medicine, Huddinge, Karolinska Institute, Stockholm, SE 141 86. Electronic address: kenneth.chien@ki.se.

PMID: 28697334
DOI: 10.1016/j.devcel.2017.06.017

Free article

Comment

Heart Regeneration 4.0: Matrix Medicine

Elif Eroglu et al. Dev Cell. 2017.

Free article

. 2017 Jul 10;42(1):7-8.

doi: 10.1016/j.devcel.2017.06.017.

Authors

Elif Eroglu¹, Kenneth R Chien²

Affiliations

¹ Department of Cell and Molecular Biology, Karolinska Institute, Stockholm, SE 171 77.
² Department of Cell and Molecular Biology, Karolinska Institute, Stockholm, SE 171 77; Department of Medicine, Huddinge, Karolinska Institute, Stockholm, SE 141 86. Electronic address: kenneth.chien@ki.se.

PMID: 28697334
DOI: 10.1016/j.devcel.2017.06.017

Abstract

The heart has a markedly limited capacity for regeneration. Reporting in Nature, Bassat et al. (2017) and Morikawa et al. (2017) have uncovered a new mechanism of Yap inhibition by the dystrophin glycoprotein complex (DGC) that is released by the extracellular matrix protein Agrin in order to promote cardiac regeneration.

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The extracellular matrix protein agrin promotes heart regeneration in mice.
Bassat E, Mutlak YE, Genzelinakh A, Shadrin IY, Baruch Umansky K, Yifa O, Kain D, Rajchman D, Leach J, Riabov Bassat D, Udi Y, Sarig R, Sagi I, Martin JF, Bursac N, Cohen S, Tzahor E. Bassat E, et al. Nature. 2017 Jul 13;547(7662):179-184. doi: 10.1038/nature22978. Epub 2017 Jun 5. Nature. 2017. PMID: 28581497 Free PMC article.

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Heart Regeneration 4.0: Matrix Medicine

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Heart Regeneration 4.0: Matrix Medicine

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