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Comment
. 2017 Jul 10;42(1):7-8.
doi: 10.1016/j.devcel.2017.06.017.

Heart Regeneration 4.0: Matrix Medicine

Elif Eroglu  1 , Kenneth R Chien  2
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Free article
Comment

Heart Regeneration 4.0: Matrix Medicine

Elif Eroglu et al. Dev Cell. .
Free article

Abstract

The heart has a markedly limited capacity for regeneration. Reporting in Nature, Bassat et al. (2017) and Morikawa et al. (2017) have uncovered a new mechanism of Yap inhibition by the dystrophin glycoprotein complex (DGC) that is released by the extracellular matrix protein Agrin in order to promote cardiac regeneration.

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  • The extracellular matrix protein agrin promotes heart regeneration in mice.
    Bassat E, Mutlak YE, Genzelinakh A, Shadrin IY, Baruch Umansky K, Yifa O, Kain D, Rajchman D, Leach J, Riabov Bassat D, Udi Y, Sarig R, Sagi I, Martin JF, Bursac N, Cohen S, Tzahor E. Bassat E, et al. Nature. 2017 Jul 13;547(7662):179-184. doi: 10.1038/nature22978. Epub 2017 Jun 5. Nature. 2017. PMID: 28581497 Free PMC article.

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