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Comment
. 2017 Jul 10;27(13):R663-R666.
doi: 10.1016/j.cub.2017.05.018.

Endocytosis: Remote Control from Deep Inside

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Free article
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Endocytosis: Remote Control from Deep Inside

Ludger Johannes. Curr Biol. .
Free article

Abstract

The endoplasmic reticulum communicates directly through membrane contacts with other cellular organelles. A new study reports that the formation and detachment of endocytic uptake carriers for the clathrin-independent internalization of the epidermal growth factor receptor is dependent on such contact sites.

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  • Reticulon 3-dependent ER-PM contact sites control EGFR nonclathrin endocytosis.
    Caldieri G, Barbieri E, Nappo G, Raimondi A, Bonora M, Conte A, Verhoef LGGC, Confalonieri S, Malabarba MG, Bianchi F, Cuomo A, Bonaldi T, Martini E, Mazza D, Pinton P, Tacchetti C, Polo S, Di Fiore PP, Sigismund S. Caldieri G, et al. Science. 2017 May 12;356(6338):617-624. doi: 10.1126/science.aah6152. Science. 2017. PMID: 28495747 Free PMC article.

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