doi: 10.1016/0361-9230(86)90020-1.
An excitatory amino acid projection from rat prefrontal cortex to periaqueductal gray
- PMID: 2869823
- DOI: 10.1016/0361-9230(86)90020-1
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An excitatory amino acid projection from rat prefrontal cortex to periaqueductal gray
Brain Res Bull.
1986 Jan.
Abstract
High affinity D-[3H]aspartate and [3H]GABA uptake, and amino acid concentrations were examined in synaptosome-enriched preparations of rat periaqueductal gray matter 6-7 days following N-methyl-D-aspartate lesions confined to medial prefrontal cortex. Specific reductions were observed in the high affinity uptake of D-[3H]aspartate (78% of control, p less than 0.025), but not of [3H]GABA. Concentrations of glutamate, aspartate, GABA, glycine and alanine were not significantly reduced in lesioned animals. These results suggest the presence of glutamatergic and/or aspartatergic projections from medial prefrontal cortex to periaqueductal grey matter.
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