Dietary Natural Products for Prevention and Treatment of Breast Cancer

Abstract

Breast cancer is the most common cancer among females worldwide. Several epidemiological studies suggested the inverse correlation between the intake of vegetables and fruits and the incidence of breast cancer. Substantial experimental studies indicated that many dietary natural products could affect the development and progression of breast cancer, such as soy, pomegranate, mangosteen, citrus fruits, apple, grape, mango, cruciferous vegetables, ginger, garlic, black cumin, edible macro-fungi, and cereals. Their anti-breast cancer effects involve various mechanisms of action, such as downregulating ER-α expression and activity, inhibiting proliferation, migration, metastasis and angiogenesis of breast tumor cells, inducing apoptosis and cell cycle arrest, and sensitizing breast tumor cells to radiotherapy and chemotherapy. This review summarizes the potential role of dietary natural products and their major bioactive components in prevention and treatment of breast cancer, and special attention was paid to the mechanisms of action.

Keywords: anticancer; breast cancer; fruit; mechanism of action; soy; vegetable.

Figure 1

Dietary natural products that showed inhibitory effects on breast cancer.

Figure 2

Structures of genistein (a); daidzein (b); 17-β-estradiol (c).

Figure 3

Signaling pathways involved in DIM-induced apoptosis in breast cancer cells.

Figure 4

Mechanisms involved in the anti-breast cancer action of dietary natural products.