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Review
. 2017:2017:5135429.
doi: 10.1155/2017/5135429. Epub 2017 Jun 18.

Preclinical Studies and Translational Applications of Intracerebral Hemorrhage

Felix Siaw-Debrah  1   2 , Mark Nyanzu  1   2 , Haoqi Ni  1   2 , Xiao Lin  1   2 , Zhu Xu  1   2 , Linhui Ruan  1   2 , Qichuan Zhuge  1   2 , Lijie Huang  1   2
Affiliations
Review

Preclinical Studies and Translational Applications of Intracerebral Hemorrhage

Felix Siaw-Debrah et al. Biomed Res Int. 2017.

Abstract

Intracerebral hemorrhage (ICH) which refers to bleeding in the brain is a very deleterious condition with high mortality and disability rate. Surgery or conservative therapy remains the treatment option. Various studies have divided the disease process of ICH into primary and secondary injury, for which knowledge into these processes has yielded many preclinical and clinical treatment options. The aim of this review is to highlight some of the new experimental drugs as well as other treatment options like stem cell therapy, rehabilitation, and nanomedicine and mention some translational clinical applications that have been done with these treatment options.

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Figures

Figure 1
Figure 1
Preclinical drugs and their targets in ICH disease process.
Figure 2
Figure 2
Potential therapeutic targets and treatments for ICH: 1. beta blocker; 2. rFVII; 3. desmoplasmin; 4. PPARγ; 5. deferoxamine; 6. celecoxib; 7. NXY-059; 8. fingolimod; 9. stem cell therapy; 10. mannitol; 11. hypertonic saline; 12. Pioglitazone.
See this image and copyright information in PMC

References

    1. Go A. S., Mozaffarian D., Roger V. L., et al. Heart disease and stroke statistics—2014 update: a report from the American heart association. Circulation. 2014;129(3):e28–e292. doi: 10.1161/01.cir.0000441139.02102.80. - DOI - PMC - PubMed
    1. Feigin V. L., Lawes C. M., Bennett D. A., Barker-Collo S. L., Parag V. Worldwide stroke incidence and early case fatality reported in 56 population-based studies: a systematic review. The Lancet Neurology. 2009;8(4):355–369. doi: 10.1016/S1474-4422(09)70025-0. - DOI - PubMed
    1. Mendelow A. D., Gregson B. A., Fernandes H. M., et al. Early surgery versus initial conservative treatment in patients with spontaneous supratentorial intracerebral haematomas in the International Surgical Trial in Intracerebral Haemorrhage (STICH): a randomised trial. The Lancet. 2005;365(9457):387–397. doi: 10.1016/s0140-6736(05)17826-x. - DOI - PubMed
    1. Mendelow A. D., Gregson B. A., Rowan E. N., Murray G. D., Gholkar A., Mitchell P. M. Early surgery versus initial conservative treatment in patients with spontaneous supratentorial lobar intracerebral haematomas (STICH II): a randomised trial. The Lancet. 2013;382(9890):397–408. doi: 10.1016/s0140-6736(13)60986-1. - DOI - PMC - PubMed
    1. Hua Y., Keep R. F., Hoff J. T., Xi G. Brain injury after intracerebral hemorrhage: the role of thrombin and iron. Stroke. 2007;38(2):759–762. doi: 10.1161/01.STR.0000247868.97078.10. - DOI - PubMed

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