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. 2017 Jul 10;109(2):0.
doi: 10.5935/abc.20170095. Online ahead of print.

Plasma Total Antioxidant Capacity and Cardiometabolic Risk in Non-Obese and Clinically Healthy Young Adults

[Article in English, Portuguese]
Jamille Oliveira Costa  1 , Cecília M Passos Vásquez  1 , Gleiciane de Jesus Santana  1 , Natanael de Jesus Silva  1 , Juciene de Matos Braz  1 , Amélia M Ribeiro de Jesus  1 , Danielle Góes da Silva  1 , Luana Celina Seraphim Cunha  1 , Kiriaque Barra Ferreira Barbosa  1
Affiliations

Plasma Total Antioxidant Capacity and Cardiometabolic Risk in Non-Obese and Clinically Healthy Young Adults

[Article in English, Portuguese]
Jamille Oliveira Costa et al. Arq Bras Cardiol. .

Abstract

Background:: The oxidative biomarkers play an important role in the genesis of cardiometabolic risk-related processes.

Objective:: To investigate the total antioxidant capacity of plasma and its association with cardiometabolic risk in non-obese and clinically healthy young adults.

Methods:: University students of the state of Sergipe, Brazil, aged between 18 and 25 years, were recruited for this study from May of 2013 and October of 2014. Anthropometric, clinical and biochemical parameters were measured and analyzed using protocols which were previously standardized and described in the literature. The measurement of plasma total antioxidant capacity was based on the ability that all the antioxidants present in the sample (plasma) have to inhibit the oxidation of the oxidizable substrate ABTS (2,2`- Azino-di-[3-ethylbenzthiazoline sulphonate]) to ABTS•+ by metmyoglobin.

Results:: Approximately 25% of the sample presented more than one component of cardiometabolic risk. Low HDL-cholesterol was the most prevalent component. Compared to absence of components, the subjects with at least one component presented greater body weight and waist circumference, higher levels of diastolic blood pressure and fasting glucose, greater total cholesterol/HDL-c ratio, and lower levels of HDL-c (p < 0.05). Fasting glycemia was the only parameter which was associated with total antioxidant capacity (R2 = 0.10; β = 0.17; p = 0.001).

Conclusions:: The plasma total antioxidant capacity was not able to predict the cardiometabolic risk components due possibly to the establishment of compensatory mechanisms that become activated in physiological conditions.

Fundamentos:: Os biomarcadores oxidativos exercem um importante papel na gênese dos processos relacionados ao risco cardiometabólico.

Objetivo:: Investigar a capacidade antioxidante total do plasma e sua associação com risco cardiometabólico em adultos jovens, não obesos e clinicamente saudáveis.

Métodos:: Estudantes universitários do estado de Sergipe, Brasil, com idade entre 18 e 25 anos, foram recrutados entre maio de 2013 e outubro de 2014. Parâmetros antropométricos, clínicos e bioquímicos foram medidos e analisados usando protocolos previamente padronizados e descritos na literatura. A medida da capacidade antioxidante total do plasma baseou-se na capacidade de todos os antioxidantes presentes na amostra (plasma) em inibir a oxidação do substrato oxidável ABTS (2,2-Azino-bis-(3-etilbenzotiazolina-6-sulfonato) a ABTS•+ pela metamioglobina.

Resultados:: Aproximadamente 25% da amostra apresentaram mais de um componente do risco cardiometabólico. Valores baixos de HDL foram o componente mais prevalente. Em comparação à ausência de componentes, os indivíduos com pelo menos um componente apresentou valores mais altos de peso corporal, circunferência da cintura, pressão sanguínea diastólica, glicemia de jejum e razão colesterol total/HDL-c, e valores mais baixos de HDL-c (p < 0,05). A glicemia de jejum foi o único parâmetro que se associou com a capacidade antioxidante total (R2 = 0,10; β = 0,17; p = 0,001).

Conclusões:: A capacidade antioxidante total não foi capaz de predizer os componentes do risco cardiometabólico possivelmente devido ao estabelecimento de mecanismos compensatórios que se tornam ativados em condições fisiológicas.

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Conflict of interest statement

Potential Conflict of Interest

No potential conflict of interest relevant to this article was reported.

Figures

Figure 1
Figure 1
Pearson correlation between plasma total antioxidant capacity (TAC) and fasting glycemia values (n = 139).
See this image and copyright information in PMC

References

    1. International Diabetes Federation The IDF consensus worldwide definition of the metabolic syndrome. [2016 Oct 10]. online. Available from: https://www.idf.org/webdata/docs/MetS_def_update2006.pdf.
    1. Leiter LA, Fitchett DH, Gilbert RE, Gupta M, Mancini GB, McFarlane PA, et al. Cardiometabolic Risk Working Group: Executive Committee Cardiometabolic risk in Canada a detailed analysis and position paper by the cardiometabolic risk working group. Can J Cardiol. 2011;27(2):e1–33. - PubMed
    1. Barbosa KB, Costa NM, Alfenas RC, De Paula SO, Minim PR, Bressan J. Oxidative stress: concept, implications and modulating factors. RevNutr. 2010;23(4):629–643.
    1. D'Archivio M, Annuzzi G, Varì R, Filesi C, Giacco R, Scazzocchio B, et al. Predominant role of obesity/insulin resistance in oxidative stress development. Eur J Clin Invest. 2012;42(1):70–78. - PubMed
    1. Crews H, Alink G, Andersen R, Braesco V, Holst B, Maiani G, et al. A critical assessment of some biomarker approaches linked with dietary intake. Br J Nutr. 2000;86(Suppl 1):S5–35. - PubMed