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Review
. 2017 Sep;16(9):871-881.
doi: 10.1080/14760584.2017.1355245. Epub 2017 Jul 28.

Mechanism of action of mRNA-based vaccines

Carlo Iavarone  1 , Derek T O'hagan  1 , Dong Yu  1 , Nicolas F Delahaye  1 , Jeffrey B Ulmer  1
Affiliations
Review

Mechanism of action of mRNA-based vaccines

Carlo Iavarone et al. Expert Rev Vaccines. 2017 Sep.

Abstract

The present review summarizes the growing body of work defining the mechanisms of action of this exciting new vaccine technology that should allow rational approaches in the design of next generation mRNA vaccines. Areas covered: Bio-distribution of mRNA, localization of antigen production, role of the innate immunity, priming of the adaptive immune response, route of administration and effects of mRNA delivery systems. Expert commentary: In the last few years, the development of RNA vaccines had a fast growth, the rising number of proof will enable rational approaches to improving the effectiveness and safety of this modern class of medicine.

Keywords: Intrinsic adjuvanticity; antiviral response; delivery system; innate immunity; optimization; self-amplifying mRNA (SAM); type I interferon.

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