Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2017 Apr 29:19:74-77.
doi: 10.1016/j.amsu.2017.03.039. eCollection 2017 Jul.

Abdominal perineal resection or wilde local excision in primary anorectal malignant melanoma. Case report and review

Saverio Latteri  1 , Michele Teodoro  1 , Michele Malaguarnera  2 , Maurizio Mannino  1 , Giuseppe Currò  3 , Gaetano La Greca  1
Affiliations
Case Reports

Abdominal perineal resection or wilde local excision in primary anorectal malignant melanoma. Case report and review

Saverio Latteri et al. Ann Med Surg (Lond). .

Abstract

Introduction: Primary anorectal malignant melanoma is a rare and aggressive tumor that carries a poor prognosis. Anorectal melanoma (ARM) is often misdiagnosed as hemorrhoids adenocarcinoma polips and rectal cancer. ARM spreads along sub-mucosal planes and is often to wide-spread for complete resection at time of diagnosis and almost all patients die because of metastases.

Presentation of the case: A 77-year-old male patient presented a history of recurrent rectal bleeding and whose histopathological diagnosis was melanoma.

Discussion: The treatment of choice remains controversial. Surgery with complete resection represents the typical treatment. However standard operative procedures related to the area of resection and lymph dissection have yet to be established. Abdominal perineal resection (APR) with or without bilateral inguinal lymphadenectomy or wide local excision (WLE) have been used to manage patients with ARM.

Conclusion: The higher serum levels of LDH and YKL-40 are suggestive for Anorectal Melanoma diagnosis. The decrease of these findings may be associated with good prognosis. The review of both APR and WLE options suggests no significant difference in survival among patients.

Keywords: Abdominoperineal resection; Case report; Melanoma treatment; Primary anorectal melanoma; Wilde local excision.

PubMed Disclaimer

Figures

Fig. 1
Fig. 1
Presence of melanoma in intestinal cells (hematoxylin and eosin staining).
Fig. 2
Fig. 2
Presence of cytokeratin (CKAE1/AE3) in intestinal cells.
See this image and copyright information in PMC

References

    1. Quan S.H.Q. Anal cancers. Squamous and melanoma. Cancer. 1992;70:1384–1389. - PubMed
    1. Trzcinski R., Kujawski R., Mik M., Sygut A., Dziki L., Dziki A. Malignant melanoma of the anorectum—a rare entity. Langenbecks Arch. Surg. 2010;395(6):757–760. - PubMed
    1. Malik A., Hull T.L., Milsom J. Long-term survival of anorectal melanoma: report of a case. Dis. Colon Rectum. 2002;45:1412–1415. - PubMed
    1. Singer M., Mutch M.G. Anal melanoma. Clin. Colon Rectal Surg. 2006;19(2):78–87. - PMC - PubMed
    1. Perrotta R., Bevelacqua Y., Malaguarnera G., Paladina I., Giordano M., Malaguarnera M. Serum markers of cutaneous melanoma. Front. Biosci. Elite Ed. 2010 Jun 1;2:1115–1122. - PubMed

Publication types