Hydroconductive and silver-impregnated foam dressings: a comparison
- PMID: 28704172
- DOI: 10.12968/jowc.2017.26.Sup7.S15
Hydroconductive and silver-impregnated foam dressings: a comparison
Abstract
Objective: As the number of commercially available wound dressings is increasing rapidly, it is important for clinicians to understand the strengths and limitations of each and to recognise relationships between wound type and dressing properties to obtain optimal healing results. Our aim is to test the antimicrobial activity of two dressings.
Method: A hydroconductive (HC) dressing and a silver-impregnated foam (SIF) dressing were compared for their potential to reduce the levels meticillin-resistant Staphylococcus aureus (MRSA). We also assessed MRSA-derived biologically active components in liquid or agar matrices, simplified models for heavily exuding or dry wounds respectively, and in an in vivo animal model with MRSA infected wounds.
Results: In the agar model (dry wounds) both dressings showed a strong reduction in MRSA activities within 24 hours post-application. The antibacterial effects of the SIF dressing were more pronounced in the liquid model, however, at an increasing cytotoxic cost. In agreement with these in vitro results, assessment of dressings using an MRSA-infected wound in an rat model showed a decrease in MRSA which was significant 7 days post-burn and inoculation, with more compromised viability of MRSA. Dressings showed a similar capability to reduced and eliminate toxic shock syndrome toxin (TSST-1) at day 7 post-burn in the animal model but not at day 4, where the SIF dressing was more potent Conclusion: These results confirm the advantages of using silver in reducing bacterial load in wound treatment, except for conditions of highly exuding wounds where the cytotoxic properties of silver may offset these advantages and HC dressing use is more suitable.
Keywords: burn infection; cytotoxicity; dressing comparisons.
Similar articles
-
The effect of negative pressure wound therapy with antibacterial dressings or antiseptics on an in vitro wound model.J Wound Care. 2017 May 2;26(5):236-242. doi: 10.12968/jowc.2017.26.5.236. J Wound Care. 2017. PMID: 28475440
-
The ability of a colloidal silver gel wound dressing to kill bacteria in vitro and in vivo.J Wound Care. 2017 Apr 1;26(sup4):S16-S24. doi: 10.12968/jowc.2017.26.Sup4.S16. J Wound Care. 2017. PMID: 28379105
-
[Comparison of the efficacies of silver-containing dressing materials for treating a full-thickness rodent wound infected by methicillin-resistant Staphylococcus aureus].Korean J Lab Med. 2010 Feb;30(1):20-7. doi: 10.3343/kjlm.2010.30.1.20. Korean J Lab Med. 2010. PMID: 20197718 Korean.
-
The effects of silver dressings on chronic and burns wound healing.Br J Nurs. 2010 Aug 12-Sep 8;19(15):S32-6. doi: 10.12968/bjon.2010.19.Sup5.77707. Br J Nurs. 2010. PMID: 20852480 Review.
-
Silver dressings--do they work?Drug Ther Bull. 2010 Apr;48(4):38-42. doi: 10.1136/dtb.2010.02.0014. Drug Ther Bull. 2010. PMID: 20392779 Review.
Cited by
-
Recent Advances in Experimental Burn Models.Biology (Basel). 2021 Jun 12;10(6):526. doi: 10.3390/biology10060526. Biology (Basel). 2021. PMID: 34204763 Free PMC article. Review.
-
Topical Antimicrobials in Burn Care: Part 1-Topical Antiseptics.Ann Plast Surg. 2018 Jan 9:10.1097/SAP.0000000000001297. doi: 10.1097/SAP.0000000000001297. Online ahead of print. Ann Plast Surg. 2018. PMID: 29319571 Free PMC article.
-
Subcutaneous toxicity of a dual ionically cross-linked atelocollagen and sodium hyaluronate gel: Rat in vivo study for biological safety evaluation of the injectable hydrogel.Toxicol Rep. 2021 Sep 13;8:1651-1656. doi: 10.1016/j.toxrep.2021.09.001. eCollection 2021. Toxicol Rep. 2021. PMID: 34567979 Free PMC article.
-
Composites Based on Gellan Gum, Alginate and Nisin-Enriched Lipid Nanoparticles for the Treatment of Infected Wounds.Int J Mol Sci. 2021 Dec 28;23(1):321. doi: 10.3390/ijms23010321. Int J Mol Sci. 2021. PMID: 35008746 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Research Materials