Dual Blades: The Role of Musashi 1 in Zika Replication and Microcephaly
- PMID: 28704657
- PMCID: PMC5775962
- DOI: 10.1016/j.chom.2017.06.015
Dual Blades: The Role of Musashi 1 in Zika Replication and Microcephaly
Abstract
Infection with Zika virus (ZIKV) during pregnancy may cause severe developmental defects in the human brain via unknown mechanisms. In a recent issue of Science, Chavali et al. (2017) identified a neural progenitor cell (NPC)-specific RNA binding protein that may underlie the high levels of ZIKV replication and apoptosis observed in these cells during congenital infections.
Copyright © 2017 Elsevier Inc. All rights reserved.
Similar articles
-
Neurodevelopmental protein Musashi-1 interacts with the Zika genome and promotes viral replication.Science. 2017 Jul 7;357(6346):83-88. doi: 10.1126/science.aam9243. Epub 2017 Jun 1. Science. 2017. PMID: 28572454 Free PMC article.
-
Zika Virus-Induced Microcephaly and Its Possible Molecular Mechanism.Intervirology. 2016;59(3):152-158. doi: 10.1159/000452950. Epub 2017 Jan 13. Intervirology. 2016. PMID: 28081529 Review.
-
Zika infection and the development of neurological defects.Cell Microbiol. 2017 Jun;19(6). doi: 10.1111/cmi.12744. Epub 2017 May 3. Cell Microbiol. 2017. PMID: 28370966 Review.
-
Progressive lesions of central nervous system in microcephalic fetuses with suspected congenital Zika virus syndrome.Ultrasound Obstet Gynecol. 2017 Dec;50(6):717-722. doi: 10.1002/uog.17303. Epub 2017 Nov 8. Ultrasound Obstet Gynecol. 2017. PMID: 27644020
-
Zika Virus Disrupts Neural Progenitor Development and Leads to Microcephaly in Mice.Cell Stem Cell. 2016 Jul 7;19(1):120-6. doi: 10.1016/j.stem.2016.04.017. Epub 2016 May 11. Cell Stem Cell. 2016. PMID: 27179424
Cited by
-
Plus-strand RNA viruses hijack Musashi homolog 1 to shield viral RNA from cytoplasmic ribonuclease degradation.J Virol. 2025 Mar 18;99(3):e0002325. doi: 10.1128/jvi.00023-25. Epub 2025 Feb 12. J Virol. 2025. PMID: 39936918 Free PMC article.
References
-
- Cernescu C, Rojanschi D. Virologie. 1981;32:199–206. - PubMed
-
- Chavali PL, Stojic L, Meredith LW, Joseph N, Nahorski MS, Sanford TJ, Sweeney TR, Krishna BA, Hosmillo M, Firth AE, et al. Science. 2017 Published online June 1, 2017. http://dx.doi.org/10.1126/science.aam9243. - DOI - PMC - PubMed
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical