Effects of phorbol ester on spontaneous transmitter release at frog neuromuscular junction
- PMID: 2870468
- DOI: 10.1007/BF00586680
Effects of phorbol ester on spontaneous transmitter release at frog neuromuscular junction
Abstract
Spontaneous transmitter release was studied at frog neuromuscular junctions exposed to the tumor promotor 12-O-tetradecanoylphorbol-13-acetate (TPA), a specific activator of protein kinase C (PrkC). TPA at concentrations between 10(-7) and 10(-6) M induced a dose-dependent increase in miniature end-plate potential frequency. This frequency increase was enhanced by raising [Ca]o, diminished by lowering the temperature of the bath and virtually abolished in Ca2+ -free Ringer. The TPA effect was only poorly reversible after washing. TPA was ineffective in increasing spontaneous release of transmitter at phosphatidylcholine-pretreated neuromuscular junctions. It is suggested that PrkC might play a role in neuromuscular transmission processes.
Similar articles
-
Influence of protein kinase C-stimulation by a phorbol ester on neurotransmitter release at frog end-plates.Naunyn Schmiedebergs Arch Pharmacol. 1988 Jan;337(1):9-12. doi: 10.1007/BF00169469. Naunyn Schmiedebergs Arch Pharmacol. 1988. PMID: 2897084
-
Stimulation of spontaneous transmitter release at the frog neuromuscular junction by 12-O-tetradecanoylphorbol-13-acetate occurs in the absence of extracellular Ca2+ and is enhanced by depolarization.Naunyn Schmiedebergs Arch Pharmacol. 1988 Oct;338(4):339-44. doi: 10.1007/BF00172107. Naunyn Schmiedebergs Arch Pharmacol. 1988. PMID: 2907607
-
Stimulation of spontaneous transmitter release by the phorbol ester, 12-O-tetradecanoylphorbol-13-acetate, an activator of protein kinase C.Brain Res. 1985 Apr 29;333(1):185-7. doi: 10.1016/0006-8993(85)90144-1. Brain Res. 1985. PMID: 2986772
-
Parallels between spontaneous release of transmitter at the neuromuscular junction and subcellular damage of muscle. Evidence for the underlying common involvement of intracellular Ca2+?Comp Biochem Physiol A Comp Physiol. 1982;73(2):147-9. doi: 10.1016/0300-9629(82)90047-0. Comp Biochem Physiol A Comp Physiol. 1982. PMID: 6128101 Review. No abstract available.
-
Spontaneous synaptic activity at developing neuromuscular junctions.Prog Brain Res. 1990;84:63-72. doi: 10.1016/s0079-6123(08)60889-4. Prog Brain Res. 1990. PMID: 1980021 Review. No abstract available.
Cited by
-
Influence of protein kinase C-stimulation by a phorbol ester on neurotransmitter release at frog end-plates.Naunyn Schmiedebergs Arch Pharmacol. 1988 Jan;337(1):9-12. doi: 10.1007/BF00169469. Naunyn Schmiedebergs Arch Pharmacol. 1988. PMID: 2897084
-
Regulation of acetylcholine receptor function by the phorbol ester TPA in rat skeletal muscle.Naunyn Schmiedebergs Arch Pharmacol. 1989 Jul;340(1):82-6. doi: 10.1007/BF00169211. Naunyn Schmiedebergs Arch Pharmacol. 1989. PMID: 2797218
-
Stimulation of spontaneous transmitter release at the frog neuromuscular junction by 12-O-tetradecanoylphorbol-13-acetate occurs in the absence of extracellular Ca2+ and is enhanced by depolarization.Naunyn Schmiedebergs Arch Pharmacol. 1988 Oct;338(4):339-44. doi: 10.1007/BF00172107. Naunyn Schmiedebergs Arch Pharmacol. 1988. PMID: 2907607
-
Phorbol dibutyrate enhances local anaesthetic action.Br J Pharmacol. 1991 Jan;102(1):146-50. doi: 10.1111/j.1476-5381.1991.tb12145.x. Br J Pharmacol. 1991. PMID: 1675141 Free PMC article.
-
Intracellular analysis of potentiation of CA1 hippocampal synaptic transmission by phorbol ester application.Exp Brain Res. 1988;71(3):588-96. doi: 10.1007/BF00248751. Exp Brain Res. 1988. PMID: 2843395
References
Publication types
MeSH terms
Substances
LinkOut - more resources
Miscellaneous