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. 2017 Oct:510:40-45.
doi: 10.1016/j.virol.2017.07.004. Epub 2017 Jul 10.

Emergence of the Asian genotype of DENV-1 in South India

D Cecilia  1 , J A Patil  2 , M B Kakade  2 , A Walimbe  2 , K Alagarasu  2 , B Anukumar  3 , A Abraham  4
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Free article

Emergence of the Asian genotype of DENV-1 in South India

D Cecilia et al. Virology. 2017 Oct.
Free article

Abstract

A large outbreak of dengue occurred in Tamil Nadu, South India in 2012 with 12,000 cases and CFR of 0.5%. Molecular characterization of virus present in the sera of dengue patients was undertaken to determine if there were changes in the virus population. All four serotypes were circulating but DENV-1 was dominant, present in 52% of the serotyped samples. Furthermore, the genotype of only DENV-1 had changed; the Asian genotype had displaced the American/African. Phylogenetic analysis revealed that the Asian genotype was introduced from Singapore and shared 99% similarity with viruses, associated with large outbreaks in Singapore and Sri Lanka. We report for the first time the emergence of the Asian genotype of DENV-1 in southern India causing an extensive and severe outbreak. The study proves how movement of DENV can affect dengue outbreaks and underscores the need for close molecular monitoring of DENV.

Keywords: Asian; DENV-1; Dengue outbreak; GI; Genotype; India; Introduction.

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