Response to Comment on "Molecular and neural basis of contagious itch behavior in mice"

Devin M Barry^{1

2}, Yao-Qing Yu^{1

2

3}, Yan Hao^{1

2}, Xue-Ting Liu^{1

2}, Zhou-Feng Chen^{4

2

5

6}

Affiliations

¹ Center for the Study of Itch, Washington University School of Medicine, St. Louis, MO 63110, USA.
² Department of Anesthesiology, Washington University School of Medicine, St. Louis, MO 63110, USA.
³ Institute for Biomedical Sciences of Pain, Tangdu Hospital, The Fourth Military Medical University, Xi'an, Shaanxi 710038, P.R. China.
⁴ Center for the Study of Itch, Washington University School of Medicine, St. Louis, MO 63110, USA. chenz@wustl.edu.
⁵ Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110, USA.
⁶ Department of Developmental Biology, Washington University School of Medicine, St. Louis, MO 63110, USA.

PMID: 28706014
DOI: 10.1126/science.aan5000

Comment

Response to Comment on "Molecular and neural basis of contagious itch behavior in mice"

Devin M Barry et al. Science. 2017.

. 2017 Jul 14;357(6347):eaan5000.

doi: 10.1126/science.aan5000.

Authors

Devin M Barry^{1

2}, Yao-Qing Yu^{1

2

3}, Yan Hao^{1

2}, Xue-Ting Liu^{1

2}, Zhou-Feng Chen^{4

2

5

6}

Affiliations

¹ Center for the Study of Itch, Washington University School of Medicine, St. Louis, MO 63110, USA.
² Department of Anesthesiology, Washington University School of Medicine, St. Louis, MO 63110, USA.
³ Institute for Biomedical Sciences of Pain, Tangdu Hospital, The Fourth Military Medical University, Xi'an, Shaanxi 710038, P.R. China.
⁴ Center for the Study of Itch, Washington University School of Medicine, St. Louis, MO 63110, USA. chenz@wustl.edu.
⁵ Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110, USA.
⁶ Department of Developmental Biology, Washington University School of Medicine, St. Louis, MO 63110, USA.

PMID: 28706014
DOI: 10.1126/science.aan5000

Abstract

Liljencrantz et al report the failure of observing contagious itch behavior using mice injected with histamine as the demonstrators. Analysis of their results shows that the histamine model is limited by inadequate frequency and duration of scratching bouts required for contagious itch test. To streamline the contagious itch test, the screen paradigm is highly recommended.

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Comment on

Comment on "Molecular and neural basis of contagious itch behavior in mice".
Liljencrantz J, Pitcher MH, Low LA, Bauer L, Bushnell MC. Liljencrantz J, et al. Science. 2017 Jul 14;357(6347):eaan4749. doi: 10.1126/science.aan4749. Science. 2017. PMID: 28706013 Free PMC article.

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Response to Comment on "Molecular and neural basis of contagious itch behavior in mice"

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