Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2017 Oct;45(5):677-681.
doi: 10.1007/s15010-017-1044-x. Epub 2017 Jul 13.

Misdiagnosis of tuberculosis associated with some species of nontuberculous mycobacteria by GeneXpert MTB/RIF assay

Yu Pang  1 , Jie Lu  2 , Biyi Su  3 , Huiwen Zheng  4 , Yanlin Zhao  5
Affiliations

Misdiagnosis of tuberculosis associated with some species of nontuberculous mycobacteria by GeneXpert MTB/RIF assay

Yu Pang et al. Infection. 2017 Oct.

Abstract

Out of 12 nontuberculous mycobacteria (NTM) species, 5 were identified as Mycobacterium tuberculosis (MTB) by GeneXpert at a bacterial load of 106. Notably, two species, including M. abscessus and M. smegmatis, were flagged as RIF-resistant MTB due to the high C(t) value of Probe E. In conclusion, our data have demonstrated that the misdiagnosis of MTB by GeneXpert assay is observed in five NTM species at a high bacterial load.

Keywords: GeneXpert; Mycobacterium tuberculosis; Nontuberculous mycobacteria.

PubMed Disclaimer

References

    1. J Clin Microbiol. 2010 Jan;48(1):229-37 - PubMed
    1. J Clin Microbiol. 2003 May;41(5):2213-8 - PubMed
    1. Sci Rep. 2014 Jul 11;4:5658 - PubMed
    1. Int J Tuberc Lung Dis. 2012 Jul;16(7):860-70 - PubMed
    1. N Engl J Med. 2010 Sep 9;363(11):1005-15 - PubMed

MeSH terms

LinkOut - more resources