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Comparative Study
. 1986 Mar;19(3):257-9.
doi: 10.1016/0166-4328(86)90026-4.

Phencyclidine-like catalepsy induced by the excitatory amino acid antagonist DL-2-amino-5-phosphonovalerate

W Koek, E Kleer, P J Mudar, J H Woods
Free article
Comparative Study

Phencyclidine-like catalepsy induced by the excitatory amino acid antagonist DL-2-amino-5-phosphonovalerate

W Koek et al. Behav Brain Res. 1986 Mar.
Free article

Abstract

This study presents experimental evidence for the mediation of a behavioral effect of phencyclidine-like drugs by inhibition of neurotransmission at excitatory synapses utilizing N-methyl-aspartate (NMA) receptors by showing that DL-2-amino-5-phosphonovalerate, a selective NMA antagonist, produces phencyclidine-like catalepsy in pigeons. This finding suggests the possibility that other behavioral actions of phencyclidine-like substances may be mediated in a similar fashion.

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