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. 2017 Oct:510:55-59.
doi: 10.1016/j.virol.2017.07.006. Epub 2017 Jul 11.

Concordance of Beta-papillomavirus across anogenital and oral anatomic sites of men: The HIM Study

Emily M Nunes  1 , Rossana V M López  2 , Staci L Sudenga  3 , Tarik Gheit  4 , Massimo Tommasino  4 , Maria L Baggio  1 , Silvaneide Ferreira  1 , Lenice Galan  5 , Roberto C Silva  6 , Eduardo Lazcano-Ponce  7 , Anna R Giuliano  8 , Luisa L Villa  9 , Laura Sichero  10 ; HIM Study group
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Concordance of Beta-papillomavirus across anogenital and oral anatomic sites of men: The HIM Study

Emily M Nunes et al. Virology. 2017 Oct.

Abstract

We evaluated the concordance between β-HPVs detected in external genital skin, anal canal, and oral cavity specimens collected simultaneously from 717 men that were participating in the multinational HIM Study. Viral genotyping was performed using the Luminex technology. Species- and type-specific concordance was measured using kappa statistics for agreement. Overall, concordance of β-HPVs across sites was low and mainly observed among paired genital/anal canal samples. When grouped by species, solely β-4 HPVs showed moderate concordance in genital/anal pairs (κ = 0.457), which could be attributed to the substantial concordance of HPV-92 in men from Brazil and Mexico (κ > 0.610). β-HPV type concordance was higher in Mexico, where HPV-19 was consistently concordant in all anatomic site combinations. Our analysis indicates that type-specific concordance across sites is limited to few viral types; however, these infections seem to occur more often than would be expected by chance, suggesting that although rare, there is agreement among sites.

Keywords: Anogenital; Concordance; Cutaneous human papillomavirus; HIM Study; Males; Oral.

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Conflict of interest statement

Conflict of Interest

No conflicts of interest are declared for any of the remaining authors.

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