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Review
. 2017:2017:8192383.
doi: 10.1155/2017/8192383. Epub 2017 Jun 21.

Salvianolic Acid Exerts Cardioprotection through Promoting Angiogenesis in Animal Models of Acute Myocardial Infarction: Preclinical Evidence

Long-Jie Yu  1 , Ke-Jian Zhang  1 , Jia-Zhen Zhu  1 , Qun Zheng  1 , Xiao-Yi Bao  1 , Saroj Thapa  1 , Yan Wang  1 , Mao-Ping Chu  2
Affiliations
Review

Salvianolic Acid Exerts Cardioprotection through Promoting Angiogenesis in Animal Models of Acute Myocardial Infarction: Preclinical Evidence

Long-Jie Yu et al. Oxid Med Cell Longev. 2017.

Abstract

Radix Salviae miltiorrhizae, danshen root (danshen), is one of the widely used Chinese herbal medicines in clinics, containing rich phenolic compounds. Salvianolic acid is the main active compound responsible for the pharmacologic effects of danshen. Here, we aimed to evaluate the effects of salvianolic acid on cardioprotection through promoting angiogenesis in experimental myocardial infarction. Studies of salvianolic acid in animal models of myocardial infarction were obtained from 6 databases until April 2016. The outcome measures were vascular endothelium growth factor (VEGF), blood vessel density (BVD), and myocardial infarct size. All the data were analyzed using Rev-Man 5.3 software. Ultimately, 14 studies were identified involving 226 animals. The quality score of studies ranged from 3 to 6. The meta-analysis of six studies showed significant effects of salvianolic acid on increasing VEGF expression compared with the control group (P < 0.01). The meta-analysis of the two salvianolic acid A studies and three salvianolic acid B studies showed significantly improving BVD compared with the control group (P < 0.01). The meta-analysis of five studies showed significant effects of salvianolic acid for decreasing myocardial infarct size compared with the control group (P < 0.01). In conclusion, these findings demonstrated that salvianolic acid can exert cardioprotection through promoting angiogenesis in animal models of myocardial infarction.

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Figures

Figure 1
Figure 1
Flow diagram.
Figure 2
Figure 2
The forest plot: effects of salvianolic acid for increasing VEGF expression compared with the control group.
Figure 3
Figure 3
The forest plot: subgroup analysis of salvianolic acid A, salvianolic acid B, and a mixture of salvianolic acids for improving VEGF compared with the control group.
Figure 4
Figure 4
The forest plot: effects of salvianolic acid in male animals for increasing VEGF expression compared with the control group.
Figure 5
Figure 5
The forest plot: effects of salvianolic acid A for improving BVD compared with the control group.
Figure 6
Figure 6
The forest plot: effects of salvianolic acid B that used pentobarbital as anesthetic for improving BVD compared with the control group.
Figure 7
Figure 7
The forest plot: effects of salvianolic acid for decreasing myocardial infarct size compared with the control group.
Figure 8
Figure 8
The forest plot: effects of salvianolic acid B for decreasing myocardial infarct size compared with the control group.
Figure 9
Figure 9
The forest plot: effects of salvianolic acid in male animals for decreasing myocardial infarct size compared with the control group.
See this image and copyright information in PMC

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